456 INOCULATION FOR PLEURO-PNEUMONIA IN CATTLE. 
animals are liberally fed, well attended to, and not over 
crowded into confined or ill-ventilated sheds. They are of 
the c£ short horn ” breed, and mostly of middle age. Various 
measures have from time to time been adopted to arrest the 
progress of the disease, but the effects have not been marked 
with any decided benefit. 
We here close the history of the disease in Mr. Paget’s 
establishment prior to the introduction of inoculation, the 
particulars of which we shall now proceed to describe. 
On the 27th of November sixteen animals were selected 
for the operation ; of these, twelve were inoculated on the 
under surface of the tail, near to its extremity, by superficial 
punctures, and four by deep punctures through the skin, 
after the manner of Dr. Willems. It is necessary, however, 
to add that these deep punctures were cleanly made with a sharp 
lancet , and not with a bad-cutting C( double-edged ” scalpel , such 
as we saw forcibly thrust through the skin, and twisted about 
in the vround by Dr. Willems. This fact led to our remark- 
ing, in the former Report, that tf£ surgical and scientific prin- 
ciples did not rule in these operations ” on the Continent ; 
and it is essential to allude to the circumstance again, because 
of the results which attended on these our first experiments. 
The material employed for the inoculation was the serous 
fluid pressed from a diseased lung, and of this two or three 
drops were placed in each wound. Care was taken to have 
this fluid as fresh as possible, and also that it should not come 
from a lung {£ over diseased for which purpose we caused 
an animal to be killed in the early stage of Pleuro- pneumonia, 
so that no untoward result might arise from a neglect of these 
precautions. We were assisted in these operations by Mr. 
H. Pyatt, veterinary surgeon, Nottingham, who is consulted 
by Mr. Paget in all cases requiring medical care, and who 
took a deep interest in these experiments. Mr. Pyatt also 
kindly undertook to watch the progress of events, and report 
to us as occasion seemed to require. 
It was decided to leave fourteen of the inoculated cows to 
mingle indiscriminately with the rest of the herd, but to re- 
move two of them to an infirmary shed, into which diseased 
animals, as they were attacked, were taken, so as to expose 
them to the more direct influence of the contagion. This 
experiment was carried out for several weeks, when it was dis- 
continued, the animals during the time remaining unaffected. 
With two exceptions, the inoculation failed to produce the 
slightest effect ; and in these two animals it was not until the 
fifteenth day of the operation that the wounds inflamed. In 
consequence of this failure we determined to m-inoculate the 
