INOCULATION FOR PLEURO-PNEUMONIA IN CATTLE. 457 
cows, which was accordingly done on December 13th. Twelve 
only out of the fourteen were however operated upon, two being 
left in order to ascertain if the previous inoculation would still 
take ; Dr. Willems, in his Memoir, having stated that a month 
sometimes elapses before any local effects are observed. No 
such phenomenon occurred in either of the cases, but, never- 
theless, as one of these cows, after inoculation, was a little out 
of health for about a week, and both Mr. Paget and Mr. Pyatt 
thought this might possibly depend on the inoculation, it was 
determined not to repeat the operation upon her. This cow, 
up to the present time, June 1st, 1853, has continued well. 
This cannot but be considered as a decided instance of a non - 
inoculated animal resisting for months, equally with those 
which were inoculated, the contagious influence of Pleuro- 
pneumonia ; for the continental authorities affirm, and in this 
we fully agree, that no constitutional effects can result from 
inoculation unless local morbid action is first produced. With 
regard to the other cow, she was subsequently rtf-inoculated, 
and lost her tail from the gangrenous inflammation which 
attended the operation. 
On one of the two original cases successfully inoculated, as 
it is ordinarily described, the inflammation was succeeded by 
ulceration of the parts adjacent to the puncture. It was 
feared that the animal’s tail would be lost ; such however did 
not prove to be the case. Further particulars, both with ref- 
erence to this last-named cow, and also the rtf-inoculations, 
will best be learned by the following note received from Mr. 
Pyatt on December 17th : — 
“ On Monday last, December 13, I went to Ruddington, and, in ac- 
cordance with your directions, I re-inoculated twelve of the cows. Not 
the slightest effect was produced by the former operation, except in two 
cases. In one, No. 19, I found the tail swollen and very sore, with a 
scab about the size of a shilling covering the place of inoculation. I 
have seen this cow daily since Monday, and, although she appears to be 
perfectly well in health, the tail is now much more inflamed, and the 
wound looking so badly, that I fear in a few days the tail will slough. 
The re-inoculations were made from a highly -diseased lung, and it seems 
to me they will all take, as the tails are now a little swollen and very 
sore when pressed. 
(Signed) “ Henry Pyatt.” 
It will be seen from this letter that the fluid used for the 
re-inoculations was the product of a more advanced stage of 
Pleuro pneumonia : to this and also to the deep punctures 
made by Mr. Pyatt, the marked inflammation that speedily 
followed, or the success of the inoculation as it is designated, 
is to be attributed. On the same day that these twelve 
animals were rtf-inoculated two others were operated on, and 
xxvi. 6‘0 
