458 INOCULATION FOR PLEURO-PNEUMONIA IN CATTLE. 
on December 1 9th, two more. These latter two were inocu- 
lated with sero-purulent fluid obtained from the inoculated 
places of other cows, being w hat is technically called “ a first 
remove” The animals bore the respective numbers of 10 and 
21, these being the marks stamped upon their horns on 
purchase, and necessary to be made mention of for the pur- 
pose of identification. 
On the 23d of December v r e paid a second visit to Rud- 
dington. The local effects of the operation, consisting of 
ordinary inflammation , advancing with greater or less rapidity to 
suppuration , were marked in all ; but, comparatively speaking, 
they w r ere slight in seven out of the twelve original cases. The 
tw r o animals operated on the same day w r ith the twelve, 
December 13th, presented a similar condition of the parts, as 
did also the two inoculated by the first remove. 
We selected seven of the most satisfactory cases from out 
of the fourteen inoculated direct with fluid from the lung, to 
give trial to r^-inoculation. On four of these the re-inoculation 
produced morbid action equally as great as the original inoculation; 
on the others it failed. This fact, which is one of the first 
importance, w r e shall have again to allude to, and therefore 
we refrain from commenting upon it in this place. Between 
the 23d and the close of the month four more cow r s were 
inoculated by <c the first remove and it was observed that 
more speedy action followed this method than that of direct 
inoculation w ith the exuded serum of the lung. 
During the month of December, Pleuro-pneumonia con- 
tinued to show itself among the animals on the farm, and 
carried off no less than seven of them — six ^o^-inoculated and 
one inoculated. The inoculated cow r w T as, however, one of 
those w hich had been operated on by “ a first remove on 
December 19th — No. 21. She was observed to be ill on the 
fifth day succeeding the operation, and an examination show r ed 
her to be the subject of Pleuro-pneumonia. The disease 
advanced so rapidly that by the fourth day of her illness it 
w T as deemed prudent to have her destroyed. The autopsy 
confirmed the correctness of the diagnosis. Mr. Pyatt w r rites 
that the right lung weighed 30lbs. 
Presuming inoculation does give security, this case must 
not be ranked among the exceptions or failures, for there 
cannot be a doubt but that the animal w^as affected with 
Pleuro-pneumonia, in its incubative stage, at the time she was 
inoculated. It should be noted, however, that the inoculation 
took effect upon a diseased animal , and that its local action was in 
no way modified thereby ; facts totally at variance W'ith the 
established law^s of inoculation for diseases which are daily 
