460 INOCULATION FOR PLEURO-PNEUMONIA IN CATTLE. 
explained. April passed without a death, but May has fur- 
nished us with three deaths, and all in inoculated animals.* 
As in by far the larger number of these cases the local effects 
differed but little from those which have already been de- 
scribed, it is unnecessary to enter into the details, but a 
summary of the whole is required. 
The inoculations, with the exception of the six first re- 
moves 33 previously described, were all made with the serous 
exudation of a diseased lung. In the major number of 
instances the inoculation tool; the first time , that is, slight 
effusive inflammation succeeded by suppuration followed the 
operation ; other animals required a second , and a few a third 
inoculation to produce these effects. 
Five cows completely resisted the inoculation , having been 
operated on many times at various intervals, without the 
slightest effect. 
In one case no evidence of the inoculation was observed for 
a month ; and it is worthy of observation that thrice during 
this time this animal was out of health, and required medical 
treatment; at the end of the month the tail became inflamed, 
and swelled to the size of a man’s arm. The inflammation 
ended in ulceration and sloughing of the skin, but the organ 
was saved. This case is also the more remarkable, as, in all 
other instances where the inflammation has run high, the 
action has quickly followed the operation. 
Eight cows lost their tails from mortification, induced by 
the operation. Evidence of this untoward result was gene- 
rally afforded about eight or ten days subsequent to the 
inoculation. 
One animal, the young bull previously mentioned, died 
from the inoculation. The mortification which succeeded 
extended upwards, affecting the perinmum, rectum, and 
adjacent parts. His death occurred on the twenty-first day 
of the operation. The lungs and viscera of the chest were 
found free from disease. 
This freedom from disease of the lungs will be hereafter 
commented on ; it is referred to by the Dutch Commissioners, 
who, also, in another of their conclusions, have truly observed 
that “when the violent action occurs, and extends to the 
more vital parts, affecting the whole system, its progress can 
* A letter received this morning, June 1st, from Mr. Paget, states that 
“ another cow, making the third, has been killed, having the complaint without 
doubt. She was of the second batch of inoculated subjects.’’ At the close of 
his communication Mr. Paget says, “ I hope, however, you will feel justified in 
recommending further trials of inoculation, for I cannot doubt that I have 
derived great benefit from its use.” 
