INOCULATION FOR PLEURO-PNEUMONIA IN CATTLE. 461 
as little be prevented and checked as the disease in general 
can be cured.” 
The two inoculated cows which were lost in February by 
Pleuro-pneumonia were attacked the one three weeks and three 
days, and the other three weeks and five days, subsequent to 
inoculation. The effects of the operation are described as 
being slight. 
The three cows which were attacked in May with Pleuro- 
pneumonia were inoculated, one in January 13th, another on 
the 20th, and the third on the 21st of the same month. The 
latter two were both observed to be ill on May 5th, being 
fifteen weeks after the inoculation. The third cow, inoculated 
on January 13th, was taken ill on May 22d, and disposed of 
two days afterwards, being eighteen weeks and three days 
subsequent to her inoculation. In two of the animals Mr. 
Pyatt reports that the effects of the inoculation were com- 
paratively slight, but yet deemed at the time to be sufficient 
to protect them. 
We now proceed to some experiments which were made in 
the Royal Veterinary College on animals also furnished for 
that purpose by Mr. Paget. On our first visit to Ruddington 
in November, it was arranged to send six cow r s to London ; 
the animals accordingly were forwarded by rail, and arrived 
safely at the College on December 10th. 
Four days afterwards, it being considered that they had 
recovered from the fatigue of their journey, we inoculated 
three of them in the usual place and somewhat in the usual 
manner, cautiously making the punctures just through the skin of 
the tail. No effects followed, and the inoculation was therefore 
repeated in the same careful manner, at an interval of eight 
days, that is, on December 22d. This inoculation also failed , 
and, instead of having recourse forthwith to deeper punctures 
ei roughly made with a had cutting instrument we determined 
to try punctures even still more superficially made, and also 
scratches of the cuticle. This was done on all the cows on 
December 30th ; as many as a dozen superficial punctures 
clustered together on the labia or perineeum, or more distant 
places on the tail , were made with a grooved needle ; in each 
case the material used being, as before, the serous fluid from 
a diseased lung. As we had anticipated, this method failed 
in every case. 
It is necessary here to state that one of the cows, which, 
from the date of her admission, three weeks before, was 
suspected to have the disease pleuro-pneumonia incubated in 
her system, from her peculiar cough and other symptoms, 
fell ill on the day but one succeeding this inoculation. The 
