INOCULATION FOR PLEURO-PNEUMONIA IN CATTLE. 463 
virus, destroyed many scores of these animals before the pock 
could be developed on the skin. Success here depended, as 
in all other cases, on the rules which we have described as 
applicable to the puncture and to the inoculating material. 
With inoculations for the prevention of natural Pleuro-pneu- 
monia the very reverse obtains ; success is connected with 
deep wounds and the employment of three or four ordinary 
drops of fluid. To return, however, to the experiments ; 
for these things wfill again present themselves for our investi- 
gation. 
28 tk . — Inoculated three of the cows by making an incision 
through the sJcin , just below the labia of each, and inserting 
into the w T ounds a small quantity of serous exudation from a 
diseased lung, using for the purpose a little friction with the 
point of the scalpel. 
Feb. ]st . — A slight tumefaction exists around the wound in 
one case. The lips of the other incisions are thickened, but 
otherwise free from swelling. 
2d . — A small pustule has formed by the side of the incision 
which was yesterday tumefied ; but the adjacent skin is free 
from undue redness. Scabs exist on the other wounds, which 
are now swollen and approaching to suppuration. 
3d . — Suppuration is established in all the cases. The tume- 
faction around the incisions is very slight, and the redness 
scarcely perceptible. 
To-day we r^-inoculated these same cows , by making clean in- 
cisions through the skin about half an inch long and about 
three inches below the others, into which was inserted with 
the point of the scalpel a little of the purulent fluid taken from 
the original inoculated places. 
4th . — The pus discharged from the original wounds is of a 
good colour, and the general condition of the parts does not 
indicate any interference with the healing process being 
quickly accomplished. 
5th . — The swelling around the second-made incisions is more 
than we have before seen. The parts are sore when pressed, 
and it is evident that the wounds will quickly suppurate. 
1th . — Pus is being discharged from the wounds ; it is white, 
but thin. The swelling of the surrounding parts is aug- 
mented, but unaccompanied with increased redness. 
Incisions were to-day made, by the side of the labia in the 
same three cows, and in like manner a little pus from the 
second-made wounds was inserted. 
8 th . — The second-made wounds are less swelled, and have a 
more healthy appearance. It will be unnecessary to allude 
to their condition again. 
