INOCULATION FOR PLEU RO-PNEUMONIA IN CATTLE. 465 
The operation was next modified by using in one wound 
the medicinal agent and in the other serous exudation . The 
order of the phenomena was now reversed, — that is, the wound 
containing the irritating agent inflamed the soonest and to 
the greatest extent; otherwise no difference was to be detected. 
The final, experiment on these animals consisted of inocu- 
lating them again with serum and roughly made punctures ; this 
perfectly succeeded, thus showing that their susceptibility to 
the local action of the morbific fluid exuded from the lungs 
was in no way destroyed by the former inoculations. 
Some few experiments have been instituted on other 
animals, to which we will now briefly allude : — 
Feb. 1th. — Two sheep, a donkey, and a dog were inoculated 
with serous fluid, and at the same time a heifer which had 
been three days previously inoculated with sero-purulent matter 
obtained from an incision on one of the cows. 
9 th. — The wounds are inflamed in the dog and the sheep ; 
but not in the donkey or heifer. 
10^. — Inflammation increased in dog and sheep : incision 
in heifer slightly inflamed : no effect in donkey. 
1 Qth. — Incisions suppurating in dog and sheep : inflamma- 
tion increased in heifer : a little swelling in the donkey. 
It is sufficient to add, that, after this date, the inoculated 
place in the heifer suppurated, the action seemingly in no 
way being controlled by the previous inoculation. In short, 
the two wounds comported themselves precisely as erasions 
of the skin would have done, received on different days by 
some slight accident. 
The incisions in the dog and sheep healed readily, as did 
that of the donkey — the latter without the production of pus. 
Subsequently two other sheep, two pigs, and a second don- 
key were inoculated in the ordinary manner. In each case 
inflammation, succeeded by suppuration, supervened. The 
sheep and pigs were inoculated on the inner side of the thigh, 
while on the opposite thigh in each animal a simple incision of 
equal dimensions, viz., about three-fourths of an inch in length, 
was made with a clean scalpel for the sake of comparison. 
These simple w T ounds healed readily in all the animals, and 
without suppuration, except in one instance where a little pus 
was formed. 
Before stating the conclusions to which we have come, with 
regard to inoculation being resorted to as a means to arrest 
the progress of Pleuro-pneumonia, we will offer a few ob- 
servations on some points contained in this Report. 
It will be seen, that, although the casualties in Mr. Paget’s 
herd at lluddington amount to the loss of tails of eight cows 
xxvi, 6l 
