INOCULATION FOR PLEURO-PNEUMONI A IN CATTLE. 477 
never fail to act, but that it often produces the death of the 
inoculated animal from the mortification which ensues. 
These phenomena are just those which medical men know to 
belong to dying, dead, and decomposing animal matters in 
these different conditions, giving us another proof thereby 
that no special virus exists in the exudations of a diseased 
lung. It must be remembered that in small-pox, to which 
we have so frequently alluded as the best example of a 
specific disease, the virus is equally present in the first as in 
the last exudations. 
As we have not to discuss the utility of other prophylactic 
measures besides inoculation in Pleuro-pneumonia, we end 
this report by giving seriatim the conclusions deduced from 
our investigations and experiments : — 
1. That inoculations made by superficial punctures and 
simple erasions of the skin invariably fail to produce any 
local inflammatory action, being the reverse of the case with 
regard to the vaccine disease, smallpox, and other specific 
affections, of which it is an indication of success. 
2. That the employment of fresh serous fluid, and a cleanly 
made but small incision, during the continuance of a low 
temperature, wfill also almost always fail to produce even the 
slightest amount of inflammation. 
3. That deep punctures are followed by the ordinary 
phenomena only of such wounds, when containing some 
slightly irritating agent. 
4. That w T ith a high temperature, roughly-made incisions, 
and serous fluid a few days old, local ulceration and gan- 
grene, producing occasionally the death of the patient, w ill 
follow inoculation. 
5. That the sero-purulent matter , taken from an inoculated 
sore, causes more speedy action than the serum obtained from 
a diseased lung, and that “removes” cannot be effected on 
scientific principles. 
6. That oxen are not only susceptible to the action of a 
second but of repeated inoculations with the serous exudation of 
a diseased lung. 
7. That an animal inoculated with the serous exudation is 
in no way protected even from the repeated action of the sero- 
purulent fluid w 7 hich is produced in the w 7 ound as a result of 
the operation. 
8. That animals not naturally the subjects of Pleuro- 
pneumonia, such as donkeys, dogs, &c., are susceptible to 
the local action both of the serous exudation from the lung 
and the sero-purulent matter obtained from the inoculated 
w r ounds. 
