POISONOUS PROPERTIES OF SULPHITE OF LEAD. 47 
rent effect was produced until the seventh day, October 30th, 
when from all appearances he was labouring under a severe 
attack of colic, which continued for nearly two hours. No fur- 
ther symptoms were manifested until the tenth day, November 
2d, when another violent attack of colic came on, which con- 
tinued for several hours. On the thirteenth day, November 5th, 
the appetite, which had hitherto been very good, began to fail, 
the food being taken with apparent suspicion. 
On the fourteenth day, Nov. 6th, the animal took with great 
reluctance his last dose ; at ten A.M. another fit came on, accom- 
panied with great prostration of strength, and at intervals there 
was great stiffness of the limbs. The dog would not allow any 
one to approach him, apparently suffering from excruciating 
pain, and manifesting the symptoms of poisoning by lead, which 
continued until death terminated his sufferings at half-past two, 
P.M. 
The total quantity of sulphite of lead taken was 280 grains. 
At the commencement of the experiment the dog weighed 16 lbs. 
12 oz. ; at the conclusion, 13 lbs. 8 oz. : thus having lost 3J lbs. 
Upon examining the liver a considerable portion was found to 
be of a dark colour, and, upon treating it in the usual method for 
the detection of lead, unmistakeable evidence of its presence 
was obtained. The brain also gave similar indications, though 
in a less marked degree. 
EXPERIMENT No. 2 . — Effect of internal and external Action 
combined . — To an old dog was administered daily twenty grains 
of carefully-prepared sulphite of lead in animal food ; in addition 
to which there was rubbed into the skin of the abdomen (the 
hair having been shaved off) daily one drachm of an ointment 
composed of equal parts of sulphite of lead and lard. No evi- 
dent symptoms appeared until the fifteenth day, when the 
dog refused to take any food ; as also on the sixteenth day, 
when he appeared extremely sleepy and inactive : he would not 
take his usual dose. On the seventeenth day he took a little 
milk only, refusing to take the sulphite disguised in various 
ways : he was evidently ill. On the eighteenth day he was 
with difficulty induced to take a small quantity of food contain- 
ing the sulphite. On the nineteenth he reluctantly took a small 
quantity of food with the usual dose of sulphite. From four to 
seven o’clock, P.M., on the same day, he barked considerably, 
appeared more restless and lively than he had previously been 
for several days : at eleven o’clock, P.M., he was prostrate upon 
the floor in a senseless state, and foaming at the mouth ; at 
intervals he with difficulty raised himself upright, but failed in 
attempting to walk. In this state he continued, alternately at- 
tempting to move about, and relapsing into a lethargic state, 
