CHLOROFORM IN TETANUS. 24 / 
lesions in the tissue forming the horn bore, to appearance, no re- 
lation to the great and remarkable changes apparent in the horn 
itself. And yet, this disparity, great as it is, ceases to excite 
surprise when we come to reflect that the extraordinary change 
is not in a constituent tissue of the body, but only in a pro- 
duct of secretion. In a word, the lesions of the matrix and of 
the papillae, although anatomically inconsiderable, are indica- 
tive of a chronic inflammation ; while, on the other hand, the 
softness and thickness of the horny matter not yet become true 
horn seems to indicate a secretion so rapid that, in its pro- 
gress, time has not been allowed for its due conversion into 
compact horny tissue.” 
To this quotation M. Bouley adds — “ Thus is microscopic ob- 
servation perfectly in accord with ordinary observation, since 
both show that, in canker, not only is there no scirrhous or 
cancerous change of the morbid tissues ; but, further, that the 
lesions of these tissues are, anatomically, very inconsiderable, 
consisting, after all, in no more than chronic inflammation. And 
besides, resulting from this double demonstration, comes the 
telling fact, that the horny secretion, so far from being inter- 
rupted, is, on the contrary, more abundant under the influence 
of canker, though the secreted product does not possess all the 
actual properties requisite ' for its due conversion into compact, 
horny tissue.’ ”* 
[To be continued.] 
CHLOROFORM IN TETANUS. 
By George T. Brown, M.R.C.V.S., Royal Agricultural College. 
The discovery of a powerful anaesthetic, and its application 
to all diseases possessing the elements, excessive irritability 
and sensibility^, are so intimately connected, that we experienced 
no sensation of astonishment on hearing that chloroform was, 
early in the hands of scientific experimenters, employed for 
such affections as obstinate intestinal spasm and tetanus. 
Applied to the last disease, I must confess it was the object 
of my most sanguine expectations, which I am fain to admit 
have not been strengthened by a review of the results attending 
its use during the last two or three years. I am yet loath to 
condemn an agent which I still think is a most important at 
the same time startling powerful therapeutic. I propose, there- 
Recueil de M^decine V6t6rinaire, de Janvier 1851. 
