106 INJECTING TUS INTO THE VEINS OF ANIMALS. 
upon the surface and in the substance of the lungs: they 
were generally about the size of a filbert, but in some places 
they occupied a single lobule, and were accurately circum- 
scribed by its outline. 
The result of this experiment, so far from supporting the 
doctrine propounded by Mr. Lee, is directly opposed to it. 
What was the cause of the vein above the opening feeling 
hard immediately after the injection it is not easy to deter- 
mine ; that it was not due to the formation of a clot is 
rendered more than probable by the fact that the hardness 
completely disappeared upon gentle pressure , Certain it is 
that the effects of pus circulating with the blood were speedily 
manifested by the acceleration of the respiration, not only 
absolutely, but also relatively to the increased frequency of 
the heart-beats. Thus, before the injection, pulse S6, 
respiration 12; two hours and a half after it, pulse 60, respi- 
ration 36. 
The post-mortem appearances of the lungs, studded with 
spots of congestion, obviously the early stage of multiple 
abscesses, were characteristic of the entrance of pus into the 
circulation, perfectly concorded with my own experiments, 
and support the conclusions I have deduced from them. 
In the second experiment (Exp. vn of series op, cit., p. 30), 
Mr. Lee, on Nov. 23d, injected about an ounce of pus into 
the right jugular vein of an ass; the vein immediately became 
corded, and the blood appeared to have coagulated in the 
vessel. The operation did not much excite the breathing, 
but the pulse, which was naturally 35 in the minute, rose to 60. 
Nov. 24th. The vein could be traced as a thickened cord 
as far as the sternum. Respiration 12 (the naturahstandard) ; 
pulse 90. 
23th. The parts around the vein were much infiltrated 
with serum ; pulse 30, respiration 12. 
26th. The wound in the neck began to suppurate, and an 
abscess subsequently formed in the course of the vein about 
midway between the opening and the sternum. The general 
symptoms continued with very slight variation until the 4th 
of December, when the animal was destroyed. 
Post-mortem appearances , — The jugular vein was found to 
have become inflamed only in the course of the circulation, 
and to be obliterated only a short distance below the external 
opening. The surrounding parts were greatly infiltrated with 
serum and lymph, and several abscesses had formed in the 
immediate neighbourhood. The lungs did not present any 
well-defined patches of congestion, as in the last-mentioned 
experiments. 
