INJECTING PUS INTO THE VEINS OF ANIMALS. 107 
Attentive consideration of the facts above recorded, make 
it obvious that the pus was not injected into the vein, but 
into the surrounding cellular tissue, a . Though the pulse 
was accelerated, the respiration continued natural ; this is the 
reverse of the former experiment, in which there can be no 
doubt that the pus did circulate with the blood. I, The serous 
infiltration of the surrounding parts noticed during life, and 
verified after death, with the additional discovery of abscesses 
in the immediate neighbourhood, is precisely what occurred 
in my experiments n and v, in which dissection proved that 
the pus had been injected into the cellular tissue. The obli- 
teration of the jugular vein, noted by Mr. Lee, is apt to 
occur from any cause which irritates the vein after an opening 
has been made into it. Thus, in experiments which I per- 
formed last year for the purpose of ascertaining the effects of 
injecting water and various saline solutions into the circula- 
tion, phlebitis occurred in several instances. 
These observations are strictly applicable to Mr. Lee’s 
vmth experiment; while, according to his narrative of expe- 
riments ix, x, xi, and xn, the injection of pus into the circu- 
lation was followed by such severe constitutional symptoms 
as to supply very weighty testimony in opposition to his 
teaching. 
In restricting my analysis to the opinions of Mr. Lee, I 
have been chiefly actuated by a sense of their importance, 
based as they are on experimental researches, and opposed to 
conclusions, which ever since their announcement were re- 
garded as marking an era in the progress of knowledge of the 
purulent infection. It was impossible to advance a step 
without admitting or refuting Mr. Lee’s statements. To the 
latter duty, I have been led by careful experiments; the 
difficulty in conducting which has given me additional cause 
for respecting and being grateful to Mr. Lee for his endea- 
vours to advance the knowledge of this highly important 
subject. In extenuation of not having as yet extended these 
researches, and analysed the opinions of all those who have 
hitherto engaged in them, I confidently appeal to the kind 
consideration of those who are acquainted with the nature of 
these investigations. I feel much pleasure in acknowledging 
the assistance I have received from my brother John, in the 
prosecution of the present inquiry. — Association Medical 
Journal . 
