56 
EFFECTS OF MEDICINE ON HORSES. 
half an ounce of the sulphate three times a-day, which they con- 
tinued until the 14th, without manifesting any change either in ap- 
petite, pulse, or general appearance. The dose was now augmented 
to an ounce thrice a-day, and at the expiration of four days from 
this, both horses manifested nausea, and appeared salivated, and 
refused their food. The medicine was discontinued for three days, 
and then resumed ; it having been remarked in the interval that 
large quantities of urine had been voided. Two days afterwards, 
the disease in the nose having shewn a tendency to spread, one 
horse was destroyed. His stomach displayed inflammation upon 
its vascular lining ; but there was no other disease. To the other, 
the doses were still farther augmented, but without any novel re- 
sult. 
April Is/, 1813, a brown gelding came under my care for treat- 
ment for glanders. He was but three years old, and looked well in 
health and fine in his coat, although he had two distinct ulcera- 
tions inside his off nostril ; his submaxillary glands enlarged on 
the same side; with corded absorbents and two or three ulcerations 
upon the off shoulder. He feeds well and his bowels act regularly. 
Let him take, morning and evening, half an ounce of the oxide 
of zinc, in ball, and have his swollen glands blistered, and his 
ulcers dressed with solut. cupri sulphat. 
3d . — Increase the dose to one ounce twice a-day. 
5th . — Let him take his ball thrice a-day : there being as yet no 
visible alteration, excepting that the ulcers in the nose are spread- 
ing. Apply to them red precipitate powder. 
9th . — The medicine is not producing any effect. A fresh ulcer 
;is visible in the nose. Let him take two ounces morning and 
evening. 
10/A. — Some knotty tumefactions are to be felt upon his quar- 
ters, and his hind legs have taken to swell. 
•11/A. — The ulceration inside the off nostril is rapidly spreading, 
though its appearance has been improved by the red precipitate. 
Two small ulcers, however, are now discoverable upon the near 
■side of the septum. Continue balls. 
,13/A. — The hind legs are so much swollen that exercise is deem- 
ed requisite. The appetite, however, continues good ; and there is 
no perceptible loss of flesh. Augment the ball to three ounces of 
zinc twice a-day. 
14/A. — The disease keeps extending, but tardily. On this ac- 
count the medicine was discontinued altogether, and the horse — 
after an interval — made the subject of a fresh experiment, the 
zinc having taken no effect whatever upon him. 
