NATURE OE GLANDERS. 
5 
of the cellular membrane precedes the formation of farcy-buds. In 
this (thickened) condition the membrane assumes a shiny and more 
humid aspect than it has in health. Then, upon divers points of 
its surface, and notably upon the middle part of the nasal septum 
and within the doubling of the nostril, make their appearance lit- 
tle white or yellowish white pimples (tltvures), rather prominent 
at their centres, with borders insensibly declining to a level with 
the surrounding membrane. These pimples or tubercles correspond 
to the course of the bundles of lymphatics, and very probably have 
their seat in those vessels, “ At least,” continues Leblanc, “ I have 
been able to prove that little shreds ( masses tlongtes), in compo- 
sition absolutely like what is found within the lymphatics of a 
farcied limb, were inclosed within their canals, from which it was 
easy, with the points of the forceps (d' un instrument) to extract 
them : they proving adherent only in certain places, marked by 
some increase of redness* * * § . I have found the greatest analogy be- 
tween these alterations and those which the lymphatic fluid com- 
monly undergoes in farcy. The two sorts of pimples in the thick- 
ened membrane, after awhile, turn soft. The lymphatic substance 
of which they are composed becomes consumed, and passes away 
with the secretions from the mucous surface. From its degenera- 
tion result pale ulcerations, reddish at their bases, and more or less 
deep in proportion to the magnitude of the pimples. Their uneven 
borders, like those of the pimples, are indented, the ulcerations re- 
sembling leaves that have been eaten by insects. On occasions, 
indeed, they present the true worm-eaten aspect (vermoulurest) : 
their edges, however, continuing rather prominent so long as any 
thickening remains. These ulcerations, no more than those super- 
vening on farcy-buds, shew no disposition to cicatrize : commonly 
they spread, and never cicatrize at allf. When very deep, and 
they take to closing, they do so through forming indurated promi- 
nent cicatrices, in substance white, corrugated, and radiated 
“ The pimples or tubercles, or tuberculous risings upon the mu- 
cous membrane of the nose, form with more or less celerity, remain- 
ing a longer or shorter time in the state of pimple. Their progress 
is quicker than is commonly believed: I know for certain that from 
* We must be careful not to confound these lymphatic coagula with the 
clots of blood contained within the small veins of the mucous membrane, which 
(as well as the former) are often colourless. — Leblanc. 
t This is the Miliary Ulceration described by Dupuy. 
I One reason for which is the nature of the (mucous) tissue in which they 
are seated, very different from the cutis vera under disease. 
§ I have often observed this puckered, radiated cicatrix : indeed, I have 
preserved several specimens of it as proofs that there are occasions on which 
glanderous chancres heal up. 
