162 
REFLECTIONS ON GLANDERS. 
diiced. Another half pint was then introduced as before, when he 
became restless and disturbed in his respiration. In another 
quarter of an hour the third half pint was administered, and the 
breathing immediately became not only difficult but stertorous : 
these symptoms continuing till another fifteen minutes had ex- 
pired, the remaining half pint, making altogether six drachms of 
aloes in solution, was poured down the vein. 
At this juncture a curious sj'mptom presented itself, which was 
the curling up of his nose or upper lip, and retaining it in that po- 
sition for several minutes; — a sure indication of nausea of stomach. 
Symptoms of distress quickly followed, laborious respiration, anx- 
iety of countenance, wandering round his box, and sweating, more 
particularly of the flank and sheath. 
After about two hours from the commencement of the experi- 
ment, the animal began to paw his litter, frequently getting up 
and down, and looking steadfastly at his flank : the sweating was 
now general and profuse, with frequent staling in small quantities, 
and deep sighing was occasionally observed. 
Between the second and third hour, an assistant, who had not 
been in any way in contact with the aloetic solution or its steam, ab- 
stracted half a pint of blood from the opposite jugular vein, and of 
which I freely tasted from a glass tumbler (my zeal in those days 
hushing every fastidious feeling), and I found the potion intensely 
bitter. 
The perspirations abated, the staling ceased, and solid faeces 
were voided from the rectum with unusual frequency, and partly 
involuntarily. 
From this time a gradual abatement of all the symptoms oc- 
curred, particularly in his respiration becoming more tranquil ; and 
at about four hours from the first injection of the menstruum he 
drank the third of a pail of cold water, but refused all food. 
I now resolved that he should be dieted and exercised in every 
way the same as a horse in ordinary purging physic. By the 
twelfth hour the faeces were in a pultaceous mass. Shortly after, 
violent purgation was set up, the animal not apparently suffering 
pain, drinking freely of cold water, but refusing food of every 
kind. 
The following day the purging continued profusely, with no other 
symptom of distress : and he occasionally picked a little hay. He 
was kept perfectly quiet, without exercise. His appetite gradu- 
ally returned, the bowels became composed, and the faeces natural, 
and in the course of three or four days the horse was himself again, 
and in excellent spirits. I had repeatedly physicked this horse for 
his owner in the ordinary way, and seven drachms was his standard 
dose. 
[To be continued.] 
