ANTIMONIAL POISONING. 351 
5. The modes in which it destroys life, when it acts as a 
fatal poison. 
6. The chemical changes which it itself undergoes in the 
organism, and the special effects of its different preparations. 
For the purpose of instituting a basis of illustration and 
argument on each of these inquiries, I pass now direct to the 
detail of experiment. 
Experiment I. — Injection of Tartar Emetic into the Cellular 
Tissue. — A large dog, in good condition, was selected for expe- 
riment. I took up a small fold of skin in the abdominal wall 
on the right side, and made an incision through it with the 
point of a scalpel, sufficiently large to permit of the introduc- 
tion of a small canula. The canula was pushed easily into 
the cellular tissue beneath, and through it one drachm of 
tartar emetic, in solution of two ounces of distilled water, was 
gently injected with a glass syringe. The salt used was 
proved, by previous experiment, to be free from arsenic, and 
w as obtained pure for the purpose. The whole of the solution 
passed readily under the skin, and the operation gave but 
little pain. On withdrawing the canula, a cross-stitch was 
passed through the wound, and none of the fluid escaped. 
The injured part was carefully swathed over, so that the 
animal could not lick it, and he was closely watched. He 
made no attempt in this direction, and indeed paid no atten- 
tion the w 7 ound. For the first half-hour after the operation 
no peculiar symptom was observed ; the animal moved about 
cheerfully, and evidenced no sign V)f pain or inconvenience. 
At the end of this time, he shivered, and immediately after- 
wards vomited freely. He now became slightly prostrated, 
and in the succeeding half hour made numerous attempts to 
vomit, in some of which efforts he threw 7 off a mucous fluid 
and solid matters. He also passed flatus freely and frequently 
from the bowels, and was once briskly purged. At the ex- 
piration of an hour, the body had become quite powerless, 
the limbs were cold, the breath w as cold, the pulse and the 
respirations were greatly reduced, and death was slowly 
taking place. There was no spasm, no expression of pain, 
but rather a comatose sinking, without further evacuations of 
any kind. Death supervened just one hour and forty minutes 
after the operation, the respiration becoming gasping at last, 
and outliving the heart’s action for full three minutes. 
Post-m.ortem examination . — The body was opened tw 7 enty 
hours after death. Dr. Herbert Barker, of Bedford, to w hom 
1 am indebted for much laborious assistance in this inquiry, 
was present. There was marked cadaveric rigidity. On laying 
bare the part w 7 here the cellular tissue was injected, slight 
