472 VESICULAR DISEASE CONTRACTED FROM SHEEP. 
parts this vesicular eruption more closely resembles the ag- 
gravated form of herpes, the vesicles being small and congre- 
gated together, with inflamed margins. In other parts, the 
vesicles are larger, and isolated, the eruption more closely 
resembling pemphigus ; in other parts, the surface appears 
blistered, as by the action of boiling water. The whole of 
the cuticle of a certain portion, one of the extremities (for ex- 
ample), is raised in continuous blisters, running into one 
another, as if the surface had been irritated by the action of 
boiling water. 
This is the general character of the eruption of the peculiar 
disease in question. Now, I will proceed to detail the symp- 
toms of the particular case to which I have adverted. 
On the 8th of April, there was admitted into Matthew 
ward, a young man named Charles Handsdale. The follow- 
ing is the account which he gave of himself : 
“ He is a single man, in good circumstances, of healthy 
parents, living at Barnet. He states that five weeks ago, 
while cutting a fresh sheep’s head, the knife slipped and cut 
his left thumb. He remembers the sheep’s lung was full of 
4 white knobs but he remained perfectly well (with the ex- 
ception of the thumb being incised, and subsequently dis- 
charging), till Saturday, April 5th, without any symptoms of 
fever. He then noticed a spot upon his lip, which he states 
was like a scald ; then a discharge from the eyes came on, 
but no headache and no shivering; and these spots gradually 
increased about his face and hands, till the disease had the 
appearance that it presented on admission.” On April 8th, 
when admitted, his condition was as follows : 
“ On his face, more especially about the chin, was a crop of 
small bullae about the size of split peas. There were also 
similar spots on the mucous lining of the lip, as well as 
on the edge of the tongue, and on the soft palate and uvula. 
There was also a purulent discharge from the left eyelids. 
On the back of the hands there were some red elevated spots 
commencing to be papular. There were also about his abdo- 
men and back, and the upper part of his thighs, many red 
elevated spots.” 
When I saw him on the following morning, his expression 
was anxious ; face flushed ; eyes suffused ; accompanied with 
a purulent discharge from the inner canthus of the left eye 
and the outer canthus of the right. There was also a puru- 
lent discharge from the right nostril. Lips dry. About his 
face, below the chin, there was an abundant crop of bullae, 
which to-day seem to be of a more pustular character. They 
are also increased in size, some being larger than a fourpenny- 
