474 VESICULAR DISEASE CONTRACTED FROM SHEEP. 
them were ruptured, and a copious discharge was taking place 
from the surfaces. The eruption was more abundant also over 
the lower extremities, ankle-joints, and over the footsteps. 
The constitutional disturbance was greater than on the pre- 
vious day. He had a very restless night, having been kept 
awake by the discharge from the eyes, and a soreness over the 
surface of the body. The pulse was accelerated (108), small 
and sharp, but compressible. The dorsum of the tongue was 
still covered with fur. His appetite began to fail. He stated 
that he was very thirsty, but had no headache. The bowels 
were opened once in the morning, the motion being confined. 
Urine free. He complained of some sore throat. There was 
slight cough and scanty mucous expectoration. 
Such was the condition on the second day. The disease 
was obviously a very peculiar one, such as is not usually pre- 
sented to our notice in this hospital, or, I believe, elsewhere. 
The moment 1 saw this young man l recognised a disease 
w'hich had been under my notice about two years ago. In 
the month of March, 1854, a young man named George 
Richardson, about the same age as this patient, was admitted 
into John ward, and he presented over the surface of his body 
an eruption of a precisely similar character to the one I have 
just described. 1 learned, on inquiring into his history, that 
he was employed as a shopman at a butcher’s, and had been 
engaged in skinning, cutting up, and dressing sheep’s-heads 
for sale, and that he had wounded himself. An eruption 
succeeded, and he came into the hospital at a more advanced 
stage of the disease, remaining there about a fortnight. He 
gradually sank, and died, worn out by the continual irrita- 
tion, and the copious discharge from the surface. The body 
was not examined. 
Dr. Burrows, after describing the details of the treatment 
in the first-named case, concludes his lecture by observing, 
that “ this disorder, as I have told you, is an undescribed dis- 
order. In its general characters it very much resembles 
acute pemphigus, but it differs apparently from it in the cir- 
cumstance that we have vesicles mixed with bullae. It is 
not either the one or the other, but the two are combined in 
the same case. It further seems to differ from pemphigus, 
inasmuch as the mucous membranes of the eye, the nostrils, 
the mouth, the tongue, the pharynx, all are implicated at the 
same time. This is the case which I have thought it worth 
while to bring under your notice to-day, because it gives me 
an opportunity of making these remarks upon the peculiar 
characteristics of diseases caused by the introduction of 
animal poisons .” — Medical Times and Gazette . 
