538 ACTION OF NUX VOMICA ON THE HORSE. 
Within fifteen minutes extremely urgent symptoms mani- 
fested themselves ; violent tetanic convulsions followed, the 
animal fell, and in about half an hour died in great agonies, 
from asphyxia. 
Second Experiment^- 
To a bay horse, labouring under acute glanders and in- 
curable, one ounce of the vomic nut in powder was exhibited, 
and the animal not allowed any water. No effects whatever 
followed its administration. 
The following day, to the same animal, another ounce was 
given, and in half an hour afterwards he was allowed to 
drink as much water as he liked. Pulse 60. This was at 
3 o’clock. 
At 5 p.m., the effects of the agent were being manifested ; 
general excitement was present, and the pulse had risen 
to 69. 
At 6 o’clock the pulse had fallen to 64, and no unfavorable 
symptom was present. He was now allowed more water, and 
in about three minutes after the pulse rose to 80, being 
very full ; and the other effects observed were — violent con- 
traction of all the muscles of the body, resembling tetanus; 
sudden snorting ; spasms of the bowels ; disinclination 
to move ; loss of power of the extremities, standing with 
his hind legs placed under the body, and the fore legs 
wide apart ; laboured respiration ; glassiness with prominency 
of the eyes ; extreme thirst. 
At 7 o’clock the pulse had fallen to 64, and the effects 
otherwise of the poison were apparently passing off. 
At 9 o’clock its action had entirely disappeared, and the 
animal was feeding as if nothing had been the matter with 
him. More water was again allowed him, but no further 
effects took place. 
