342 INOCULATION FOR THE MOUTH AND HOOF DISEASE. 
question which farther experiment alone can solve. That inocu- 
lation could produce exemption from taking the disease again in 
its worst form is, in my opinion, problematical. 
Inoculatory experiments, partly undertaken with this view, and 
partly for the purpose of inquiring into the contagiousness of the 
disease, have already been made by many persons, and, among 
others, by Buniva. (Calendario della Soc. Agraria, 1812, and 
Annal. de PAgriculture Frangois, tom. xlix, p. 360). Oxen and 
calves were inoculated with this disease, and the following was 
the result : in some, simple fever arose without any other disease ; 
while, in many, an eruption about the mouth and hoof appeared. 
The former were ill only six days, while the latter suffered for 
twenty days, or more. In both the disease could be again in- 
duced by inoculation. 
In 1815, Herr Brauell, royal veterinary surgeon, at Weimar, 
produced this disease in cattle and sheep by inoculation on the 
ear. In 1816, Professor Renner inoculated for this disease in 
Jena and its neighbourhood (see Dr. O. F. G. Hoffman diss 
inaug. de incitione. Febr. bullos epizootic®, Jen. 1816;. Sub- 
sequently, Wirth inoculated at Zurich (Archiv. fur Thierhielkunde 
Neue Folge. bd. i, s. 227), as did my colleague. Dr. Spinola, of 
Berlin, and both with similar results. Rodiger, in his work 
(Erfahrung liber die bosartige Klauenseuche Chemnitz, 1822), 
devotes a whole chapter to inoculation (chap, iv, s. 47, 55), and 
Dr. Bartels, of Helmstadt, has given some very luminous de- 
scriptions of inoculation (ind. Oekonom. Neuigkeiten, 1842). 
According to him, it protects the animal not only from a return 
of the disease, but also serves as a precautionary measure incases 
of infection. A general and normal eruption is thus produced ; 
and the equal and quick course of the disease when resulting from 
inoculation renders it easy and not expensive to bestow that care 
and attention on every animal which is necessary and beneficial. 
The farmer is thus enabled to avoid those diseases of the hoof, 
often so fatal, and the animals do not lose so much in flesh, milk, 
and growth. Draught cattle are also much sooner fit for work. 
Dr. Bartels made use of that matter for inoculation which was 
taken from animals in which the pustules had become fully and 
generally developed. He also took it from the mouth about the 
third or fourth day after the commencement of discharge. He like- 
wise endeavoured, as much as possible, to inoculate animals with 
the matter taken from one of a similar species, and even breed, 
and not from any others, if he could avoid it. 
He inoculated in the following way : — a cow or sheep was fed, 
and, when it had done eating, its mouth was wiped clean with a 
woollen cloth, and then some of the mucous saliva taken with the 
