350 
EFFECTS OF MEDICINE ON HORSES. 
March 21st. — He took 3i of the medicine in his pailful of wa- 
ter, and had the same repeated in the evening. 
22 d. — Two drachms of the solution twice a-day. 
23 d and 24 th. — Three drachms twice a-day. 
25th y 2 6th, and 27 th. — Half an ounce twice a-day. 
2 8th. — Five drachms twice a-day. 
29 thy 30th> and 31sf. — Six drachms twice a-day. 
April 1st. — For the first time he refused his food; inconse- 
quence of which the dose was given but once on this day. 
2d. — His appetite being amended, he took half an ounce twice 
a-day. 
3d . — He took five drachms twice a-day. 
4 th t 5th, and 6th. — He took six drachms twice a-day ; though 
on the last day he again loathed his food. 
7th. — He could not be induced to drink any of his water, and 
therefore seven drachms of the solution were mixed with a pint 
of water, and administered as a drench. 
8 th. — The same drench was twice repeated, notwithstanding 
his appetite had again become fastidious. 
9 th. — Only 3 v j were given morning and evening. 
10 th. — Being more off’ his feed, the dose was reduced to 3iij 
twice a-day. 
IliVi and 12 th. — Only 3ij were administered twice a-day. 
13 th. — The same dose was given but once. 
14th . — His appetite having completely failed him, the medi- 
cine was discontinued. His pulse is 60, and he has visibly lost 
much flesh, being reduced, from a fat and fine-coated horse, to a 
thin, rough-coated, unhealthy looking animal. No effect ap- 
peared to have been produced by the arsenic on the glanders, 
but the disease made its usual progress. 
18 th. — The animal was destroyed. There is, unfortunately, 
no account of the post-mortem state. 
Case II. — May, 1812. Ahorse, looking well in condition, 
and feeding well, with a pulse ranging between 40 and 50, and 
bowels in their natural state, but affected with glanders, having 
ulceration within both nostrils and enlargement of the sub- 
maxillary lymphatic glands, was subjected to the operation of 
arsenic. 
May 1 6th. — The first dose administered was an ounce of a 
solution of arseniate of Potash, in which was contained half a 
drachm of arsenic*. 
* The Fowler’s solution employed in these experiments had, therefore, 
the strength of nearly four grains to the fluid drachm ; whereas the Liquor 
Arsenicalis of the London Pharmacopoeia contains but half a grain to the 
drachm. 
