EFFECTS OF MEDICINE ON HORSES. 
651 
1 7 th . — Off his feed. Repeat the dose. 
18/A. — More off his feed ; pulse 60. Repeat medicine. 
19th . — Eats little or nothing ; seems very sick. Continue the 
medicine. 
20th . — Expressing a great deal of pain by pawing, gnawing 
his hay, &c. ; respiration quickened and oppressed ; failure of 
strength, manifested by staggering and all but falling when he 
moves ; pulse 90, and thready. Discontinue the medicine. At 
half-past ten o’clock, p. m., he died. 
The first circumstance noticed, on proceeding to make a post- 
mortem examination, was a most oppressive fcetor proceeding 
from the cavity of the abdomen, which became so intolerable the 
instant escape was given to the gas with which the bowels were 
distended, that myself and others in attendance not only found 
ourselves compelled to compress our nostrils between our thumbs 
and fingers, but at length were obliged, so overcoming and dis- 
agreeable was the stench, to leave the box for a minute or two. 
As soon as we had recovered somewhat from the effects of it, we 
proceeded with our examination. 
The Stomach exhibited no alteration upon its cuticular 
surface, but upon the villous existed a great deal of inflamma- 
tion ; and the inflammation appeared in spots or patches. In 
places where the reddening was most intense the texture of 
the tunic appeared softened and disorganized ; and, in addition, 
the entire villous coat presented much increase of substance, or 
thickening. The inflammation extended into the duodenum, and 
also was, in places, apparent in the other small intestines ; but as 
for the large intestines, the ceecum and colon at least, they were in 
a perfectly gangrenous condition. Their villous linings, particu- 
larly that of the blind pouch of the caecum, were both black and 
rotten, owing, perhaps, to the lodgment and longer detention of 
the medicine in these parts. 
The Liver was paler than usual ; but otherwise without appa- 
rent change. 
The Lungs were tuberculated, and, in other respects, shewed 
the prior existence of disease. They were, however, in addition, 
greatly congested, and quite black, a condition partly ascribable 
to the hard death the animal died; but also, no doubt, owing to 
the arsenic — it being evident, from their odour, that they con- 
tained some of the same kind of gas which pervaded the abdo- 
minal cavity. 
The former of these cases exhibits a good example of what we 
may expect from arsenic in solution, given in over-doses — in doses 
such as the system cannot support. The latter one instructs us 
