VETERINARY SCHOOL OE ALFORT. 
395 
We have witnessed in our hospitals the spontaneous cure of five 
horses affected with acute glanders perfectly developed. A dis- 
ease which exercises so great an influence on the public health 
deserves our attention and study. With the intention of elu- 
cidating its history, we have continued a series of experiments 
commenced two years ago. We have endeavoured to ascertain, 
by a succession of inoculations, whether acute glanders loses its 
contagious property by reproduction ; and we have seen that at 
the seventh generation the virus was as active in its effects as 
when it proceeded from spontaneously developed disease. 
We have also tried whether the matter of the nasal discharge 
and dried in the open air, preserves its virulent property for any 
considerable length of time ; and we have seen the eschars pro- 
ceeding from this desiccation macerated, and distilled in water, 
and yet the part being inoculated, at the end of six weeks acute 
farcy has appeared. 
We have tried whether the virulent matter existed elsewhere, 
as well as in the products of the nasal secretion, and we have 
seen matter from ulcers of the lungs very rapidly producing acute 
glanders. 
Blood possesses the same virulent properties. Injected imme- 
diately after its extraction from a vein into another vein of a 
sound horse, it produced, at the end of four or five days, glan- 
derous eruption. 
With the purpose of assuring ourselves once more whether 
glanders could be transmitted to other animals beside the horse, 
we attempted its inoculation on four cows, three sheep, six dogs, 
and six rabbits, trying the effect of the virus on as many horses 
at the same time. All the inoculations with matter of glanders 
on the horse produced, without exception, their accustomed effect 
but our attempts were completely fruitless on the others. It has 
been the same with the experiments of cohabitation continued 
for more than six months between horses attacked with acute 
glanders and animals of different kinds. 
Chronic Glanders. 
In this year, as in all the preceding ones, we are compelled 
to confess the complete impotency of the efforts that we have 
made to cure chronic glanders. This statement will astonish 
no one who is aware of the irreparable lesions which the attack 
of this disease leaves in the general organization. When they 
have assisted at the opening of horses really attacked with chro- 
nic glanders — when they have seen the profound destruction 
of the membrane which lines the interior of the nostrils — the 
collections of purulent matter in cavities almost closed — the 
complete transformation of the pellicular membrane which once 
