SMALL-POX IN SHEEP. 
465 
does come. To sum up these inoculations, extending over a period 
from 1805 to the present day, consigned now to the annals of 
science, it appears that, of 10,416 sheep inoculated, coming from 
flocks suffering under isolated and enzootic pox, 321 have died, 
and 10,095 have been saved, bringing the loss to 3 per cent. 
In the case of epizootic pox, where the disease already existed 
in the flock, and consequently where such sheep as recovered, 
though they appeared healthy, might have lurking within them 
the contagious germ in a state of incubation, 28,533 head were 
inoculated, out of which number 285 died and 28,248 recovered; 
bringing the per centage to about 1 in 100. 
These general results, then, are most favourable to inoculation. 
Let us now examine the results obtained throughout France. 
M. Gayot assures us he has inoculated upwards of 10,000 sheep 
in the departments of La Marne and La Haute Marne during the 
prevalence of epizootic small-pox ; and that, while the mortality 
ran as high as twenty per cent, among the subjects of the natural 
pox, it amounted to no more than 2 in 300, taking the average, 
among the inoculated sheep. Messrs. Miquel and Thomieres ino- 
culated, between the 19th of December 1820 and the 15th of 
January 18*22, 17,044 sheep, constituting 84 flocks, of which 42 
were in part infected with the natural pox at the period of inocu- 
lation ; and those gentlemen made at the time the following remark, 
one that I have deemed worth recording: — 
“ Notwithstanding that the epizootic disease is already present 
among the flock,” say those two able veterinary practitioners, “we 
must not shrink from inoculating all such as maintain the aspect of 
health. Even though the eruption have shewn itself upon two- 
thirds of the flock, we may reckon with certainty on saving such 
sheep as have not yet imbibed the germ of contagion. "We inocu- 
lated the flock of M. Antoine Rautier d’Adge, consisting of 300 
head, of which forty already shewed the natural pox. In conse- 
quence of the remainder being inoculated, not one of them was lost. 
“ In another flock, consisting of 185 sheep, small-pox had seized 
upon two- thirds. Out of the remaining third, which were inoculated, 
five were lost. This mortality may appear considerable by the 
side of the former one. The owner of them, however, possessed 
no means of separating the animals in health from the sick ; added 
to which, a hot humid wind from the south contributed not a little 
to aggravate the evil*.” 
F rom 1822 to 1824, M. Guillaume, veterinary surgeon at Issoudun, 
practised inoculation in the departments of Indre and Cher in 
every season of the year. Among twenty-seven flocks, consti- 
* Miquel and Thormiere’s Notes on the Inoculation of Sheep-pox, pp. 6, 7, 
and 8. 
VOL. XXL 3 R 
