412 ON IODINE AS A REMEDY FOR GLANDERS. 
trial are superior to my own, and whose peculiar province it is 
to attend to disease in the lower animals : it is amongst these 
that the drug can be extensively employed, and a series of ex- 
periments can be instituted sufficiently numerous to prove the 
efficacy or the inutility of this important medicine. 
The physiological differences which exist between the lower 
animals and man militate against the accurate investigation of 
the action of medicines, as applicable to diseases of apparently 
similar nature, generally ; but in a transmitted disease, the 
product of morbid poison exciting in the two similar symptoms, 
when inoculated, and having an affinity to similar tissues in 
both, a remedy that has displayed power in one, may be expected 
to evince a like power in the other, under favourable circum- 
stances for application. 
Such considerations lead me to hope that a farther trial of 
iodine will be found efficacious in certain forms of the disease 
arising in man, as it has proved so effective in one of the worst 
forms of the affection in one of the lower animals : but the in- 
vestigation of its properties in subduing the fatal progress of 
glanders will require close and accurate application, and an 
attention as to quantity, commensurate with the nature and 
violence of the attack. From the singular effect elicited in the 
experiment I am about to mention, I should be inclined to place 
more faith in iodine than in any other medicine yet employed ; 
but I would suggest the necessity of giving it in large and re- 
peated doses, and to persevere in its use until its action was 
fully displayed. 
The horse, the property of my brother-in-law, was seized with 
what was pronounced to be glanders by the f^riers who attended 
it, several weeks before iodine was recommended. The disease 
was then in an advanced stage, the horse having ulcerations of 
the nostrils, so far as could be observed, particularly in one of 
them, and enlargement of the glands under the jaws. The various 
means employed in such affections had been resorted to without 
effect, and the animal getting so weak as to be scarcely able to 
stand, was recommended to be shot. It was at this advanced 
period that I by chance saw it ; and thinking it a good opportu- 
nity to try the power of iodine, I requested the groom to admi- 
nister 150 drops of the strong tincture, three or four times a-day 
in water. The iodine was given regularly for the space of six 
weeks. Not fewer than 450 drops, and frequently 500 or 600 
were exhibited daily. In a few days the benefit of the drug was 
evidenced, and at the end of seven weeks the horse was nearly 
well. The animal is, at present, the property of another person, 
and is considered by him to be one of the best in his stable. 
