528 THE DISCOVERY OF THE URINO- BILIARY CALCULUS. 
cording to their frequency and rarity, the observation we have 
this day the honour of communicating to the Society is intended 
to shew the analysis of vesical calculi presenting, among their ele- 
ments, the re-union of two organic principles; — one belonging ex- 
clusively to the products of the renal and urinary secretions ; the 
other being as yet discovered nowhere save in the secretion of the 
liver. In this point of view these calculi have appeared to merit 
the attention of veterinarians ; and the fact which we believe to 
have escaped observations, in man as well as in animals, may justify 
the name we have given to the calculus, of urino-biliary. 
The animal, the subject of the present observation, was a bitch 
of large size, of the bull-dog breed, who died last month at the 
College at Alfort, of ascites. In her ureters, kidneys, and bladder, 
there were a considerable number of small calculi, of very irregular 
shape, and of a fine grass-green colour, which we were anxious to 
collect for the purpose of examination. Among the alterations ob- 
served ought to be mentioned that the renal substance exhibited a 
light yellow tint; and that the liver contained within its substance 
little whitish granulations having bases of phosphate of lime, with 
small cysts, perfectly circumscribed, of the size of large peas, which 
inclosed a soft matter, of a greenish grey, constituted of serni- 
coagulated albumen, mingled with a little of the green aliment of 
the bile, and phosphate and carbonate of lime. 
The Chemical Analysis of the Calculi, conducted with 
every care, has given the following results : — 
Uric acid 62 5 
Green matter of bile .... 12T 
Ammonia 25*4 
Traces of phospate of lime 
100-0 
Or, in consideration of the order in which the above products 
ought to be arranged, 
Urate of ammonia 
87-9 
Green matter of bile . 
121 
Traces of phosphate of lime 
1000 
If the presence of uric acid, at other times rare in the vesical cal- 
culi of dogs, whose existence we have satisfactorily shewn in the 
present case, renders this observation curious, it is still more so 
in this respect, in our opinion, on account of this acid, peculiar to 
the urine of man and some carnivorous animals, being accompanied, 
in these calculi, with a principle proper to the secretion of the 
liver. 
