1 883.] New Researches on Canine Madness. 59 
the same virus, and that it is possible to proceed experi- 
mentally from either of these types to the other. 
Nothing is more fluctuating than the symptoms of canine 
madness. . Each case has some characters peculiar to itself, 
and there are grounds for admitting that these characters 
depend on the points of the nervous system where the virus 
is localised. 
In the saliva of a rabid animal the virus is associated 
with various microbia, and the inoculation with this saliva 
may bring on any one of three kinds of death, viz., death by 
the new microbion which the author has described as the 
salivary microbion, death owing to an extensive production 
of purulent matter, or, lastly, death by what is commonly 
called hydrophobia. Hence it will be perceived that the bite 
of a rabid animal is an affair even more serious than is com- 
monly imagined, since a triple danger has to be encountered. 
I may add that a bite even from an animal in a normal state of 
health is far more to be dreaded than a wound received from 
any clean tool or weapon. 
The rachidian bulb of a person or of any animal who has 
died of rabies is always virulent, but the virus may be also 
found in the whole brain or in some of its parts, or in the 
spinal marrow. The virulent matter taken from the spinal 
marrow is quite as deadly as that from the rachidian bulb 
or from any part of the brain, and the virulence persists un- 
til the nervous matter is attacked by putrefaction. 
Rabies communicated by the injection of the virulent 
matter into the blood offers characters which often differ 
decidedly from the furious madness brought on by a bite, or 
by placing the virus in contact with the brain. Hence it is 
probable that many cases of so-called mute madness escape 
observation. 
The author is led to the belief that in inoculations byway 
of the blood the spinal marrow is the part first attacked. 
Inoculation in a dog with the saliva or the blood of a rabid 
animal does not always prove fatal, but such a recovery is 
no certain protection against the effects of a fresh inoculation 
with the pure matter of rabies, whether by application to the 
brain or by injection into a vein. 
M. Pasteur has met with cases of spontaneous recovery 
in dogs after the first symptoms of rabies had appeared, but 
never after the disease has reached its acute stage. He has 
also observed cases where the first symptoms had subsided, 
but the disease had nevertheless reappeared after a long 
interval (two months) without any fresh infection. Under 
such circumstances the acute symptoms were followed by 
