500 
ON GLANDERS. 
centre was formed of a white matter, mingled with red, and of 
the consistence of cheese. Some of these granulations were 
softened in the centre, and the matter which formed them was of 
the nature of pus. The right lung presented the same changes, 
but not so much advanced. The lymphatic ganglions under the 
tongue were exceedingly vascular, and infiltrated by a citrine- 
coloured fluid, that may be easily pressed out of them. Their 
substance also contained some purulent depots, which filtrated 
across the openings of numerous vessels, the interlacement of 
which constituted the ganglionic substance. 
The liver was increased in size, and its substance was diffluent. 
There were not any granulations in its substance. 
The cellular tissue in the oedematous parts was infiltrated by a 
great quantity of citrine-coloured serosity, that gave it the re- 
markable trembling appearance of gelatine. The same infiltration 
existed around the farcy cords and buttons. The centre of these 
cords was formed by a lymphatic engorgement of purulent matter. 
The buttons or pustules consisted of an induration of subcutaneous 
cellular texture in a circumscribed space, with a central collection 
of pus or purulent serosity. 
The heart was flabby, and discoloured as if it had been baked. 
Black ramifications followed the course of the veins. Ecchvmoses 
lay under the serous membrane. There was no discoloration of 
the internal surface of these vessels. The blood was rarely co- 
agulated in the larger vessels. There was no trace of inflamma- 
tion in any of the articulations. 
That no doubt might remain as to the nature of the disease 
produced by this experiment, another horse was inoculated with 
the matter discharged from the nostril of the first. This was a 
strong horse, of excellent constitution, but which had been under 
treatment for a considerable period, on account of caries of the 
bones of the foot. He was inoculated on the 28th of April with 
matter taken from the nostril of the mare. Four punctures were 
made. On the following day these punctures were covered with 
a new layer of purulent matter from the glandered mare. 
On May 2d these punctures began to exhibit the peculiar en- 
gorgement that infallibly announces the virulent action of the 
poison by which this animal was inoculated. 
From the 2d to the 13th of May all the characteristic symp- 
toms of acute glanders successively appeared, and on the 14th 
the animal died. The post-mortem examination left no doubt as 
to the accuracy of our prognosis during life. The horse evidently 
died of acute glanders. 
This experiment was not the only one which we made, and with 
the same result. 
