SMALL-POX IN THE DOG. 
431 
vaccinated the animal — that three other dogs of the same litter as 
himself had been vaccinated, and had been preserved from that 
dreadful malady, from which it appeared that they had no other 
chance of escaping. Time, however, unfortunately proved that 
he was wrong. 
I had at that time several young dogs in my infirmary, and 
among them 1 remarked one that was variolous. I immediately 
adopted such measures, that the greater part of them very soon 
began to exhibit the same eruption. I thus executed that which 
I had long premeditated, and I inoculated two other young dogs 
with the virus of variola taken from a pustule in a serous state. 
In one of them, pustules developed themselves only around the 
puncture ; in the other, the eruption extended to the belly, the 
chest, and the inside of the thighs, the inoculation having been 
made on the inside of the thighs. This dog had a well-marked 
eruptive fever. The disease ran its course in the ordinary way, 
and became perfectly cured. The other had no disease at all. 
Believing that the variola would attack other dogs in my 
establishment, 1 determined to inoculate with the vaccine matter 
as a preservative. I wished also to ascertain whether the vac- 
cine disease was a preservative against distemper. I, therefore, 
vaccinated three dogs, but neither of them became infected. 
The skin around the punctures became a little red and promi- 
nent, and the inflammation resembled that which would be pro- 
duced by the prick of a lancet not charged with any virus, and 
it speedily disappeared. I repeated the experiment with fresh 
virus, but with no better success. 
Among the dogs vaccinated, or rather punctured, or merely 
pricked, none had the variola ; not, I apprehend, because they 
had been punctured, but probably their constitutions had not 
been disposed to take on the infection. Among the dogs were 
many that had distemper. This last fact was not an objec- 
tion to vaccination as a preservative against the disease, since 
more than once the vaccine disease did not develop itself. The 
result of these experiments, however, was, that the vaccine dis- 
ease was not communicated to the dog by inoculation with vac- 
cine matter. 
I return, however, to the Newfoundland dogs, of which I have 
before spoken. I had been assured that these dogs had been 
vaccinated, but had not taken the disease. Eight days, how- 
ever, did not pass before one of the supposed vaccinated dogs 
arrived with evident distemper. He had lost his spirits and his 
appetite — he had cough — discharge from the nose — also from 
the eyes, and, a little afterwards, diarrhoea, flux of blood, and 
suppurative pneumonia. This dog died. 
I observed in this dog, — -that which 1 had often remarked in 
