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CONTRIBUTIONS TO 
was essentially phthisis, I determined to push the iodine to its full 
extent, especially as no lesion had been left in the stomach or intes- 
tines of the female. The dose was accordingly increased until it 
reached twelve grains morning and night, which he regularly took. 
Sometimes he rallied, but at other times the labour of respiration 
was dreadful, and he threatened to die every minute. He lingered 
on until the 28th, and then he died. His death struggles were 
fearful, and there was a considerable discharge of blood and pus 
from the nose. 
On opening the abdomen, there was no appearance of disease 
beyond a slight congestion of the liver ; but on cutting into the 
stomach, there appeared an inflammation and softening of the mu- 
cous membrane, and extending into the duodenum, more intense 
than I have been accustomed to see in phthisis, and which I am in- 
clined to attribute, partly at least, to the iodine. It had nothing to 
do with the death of the animal ; but it indicated that we had pushed 
the iodine quite far enough. 
The lungs were almost universally hepatized. It was wonder- 
ful that the process of respiration was carried on at all. In some 
places there was a dense substance of a mottled, marbled appear- 
ance ; in others, the bright red of the hepatization shewed that it 
was of very recent formation ; in others, the process of decomposi- 
tion had commenced, and there were caverns, one of which would 
have held four or five ounces, and which contained a black and 
putrid fluid. There was one large hydatid embedded in the lung, 
that contained at least six ounces of fluid. There was not a single 
tubercle — not even the minutest granulation — and the pleura was 
comparatively slightly affected : certainly there was no adhesion. 
Then what was the character of the disease in these animals! 
There was, at least, a predisposition to phthisis. If the tubercles 
did not exist in the female prior to the inflammatory attack of the 
lungs, they were produced very soon afterwards. In the male, 
perhaps the iodine contributed to prevent their development, for 
the caverns which were found in the lungs very much resembled 
those which I have been accustomed to see in old tubercular affec- 
tions. 
The inflammation of the lungs may, perhaps, be in some measure 
accounted for. There are occasionally, by some or other of the 
numerous animals which that repository contains, some villainous 
compounds of smells emitted, in order to get rid of which it is some- 
times necessary to open the lower window which blows into the 
tiger’s cage. In the night of the 16th, the external thermometer 
was eleven degrees below the freezing point. On the following 
night it was nine degrees above the same point, a change of tem- 
perature sufficient to try the constitution of a far less phthisical sub- 
