546 
ON INOCULATION WITH THE 
C. The Method of Inoculation. — Munnicks passes a saturated 
thread through the eye of a sharp needle, two inches in length ; he 
introduces the needle under the skin at the inside of the thigh, and, 
giving it a perpendicular direction, in order that the purulent dis- 
charge may readily run off, he brings it out at the distance of half an 
inch from the first insertion — he ties the two extremities of the 
thread as he would a common seton, and leaves it from twelve 
to twenty-four hours, a sufficient interval for the contagion to be 
communicated to the animal, if he is susceptible of it. The same 
method is adopted in Denmark by Witer-Bergen, and Bulow. 
Claus Detlof makes an incision of an inch and a half in length 
into the skin, between the dorsal portion of the spine and the ribs, 
and in a tranverse direction, and he places in it some threads satu- 
rated with the virus, and which he covers and keeps in their place 
by means of an adhesive plaister. 
Girard and Duprey find fault with this method of proceeding. 
The virus, say they, being deposited in the cellular tissue, may be 
decomposed there, and may produce those obstinate gangrenous 
tumours which occasionally arise from the inoculation of putrefy- 
ing matter. They prefer the lancet or the grooved needle, which is 
an easier mode of operating, more expeditious, and is rarely fol- 
lowed by the gangrenous tumours alluded to. The instrument is 
charged with the virus, it is plunged with precaution under the epi- 
dermis, and care is taken that, in withdrawing it, the virus is left in 
the little incision. The poison should be inserted in those parts 
where the integument is thin and denuded of hair, and the teats 
or the lips of the vulva in cows, or the muzzle, & c. The effect is 
not so certain where the skin is hard, thick, and hairy. 
The immediate and consecutive Effects of the Inoculation. — The 
inoculated typhus, according to Camper, begins to manifest itself 
from the fourth to the sixth day, and, during that time, there is no 
visible change in the health of the animals. On the sixth or 
seventh day the milk begins to diminish — the conjunctiva becomes 
red — there is shivering and grinding of the teeth, and loss of appe- 
tite. The ears are alternately hot and cold, and the bowels become 
somewhat constipated. On the eighth or ninth day, the beasts 
begin to utter the most plaintive lowings — the breathing becomes 
laborious, and purging commences. About the tenth or eleventh 
day, the nostrils were obstructed by a sanious humour ; and, by the 
twelfth or thirteenth day, the crisis of the disease had arrived. In 
some cases the disease was so slight that its symptoms were scarcely 
distinguishable : in other animals, however, it broke out with vio- 
lence, rapidly assumed its greatest intensity, and became fatal if it 
was not attacked in its earliest stage. 
From a comparison of numerous cases, it resulted, 
