MATTER OF TYPHUS. 
549 
Dufot, speaking of this inoculation as practised in Holland, says 
that one beast received the disease a second time by the same 
means. 
Vicq. d’Asyr relates an example of a second infection, but he 
regards it as a doubtful case. “ I must add one word,” says the 
Marquis de Courtivron, “ on a subject on which it is necessary that 
the public should be set right. During some late years, in Bresse, 
the Maconnais, and Bugey, it was thought that the cattle that had 
recovered from the disease, after an exterior eruption that marked 
the danger to which they had been exposed by the pustides with 
which they were covered , could never again be attacked by this 
fearful malady. On the faith of this opinion, an animal that had 
thus recovered was frequently sold for more than six times his 
value in ordinary times. It has, however, happened that this 
beast has died soon after it came into the hands of the purchaser ; 
or he has been infected with the disease a second, a third, and even 
a fourth time. An animal that has escaped a second time has 
perished when the malady has been once more prevalent in the 
country ; and this has proceeded to such an extent, that we have 
been enabled to collect a great many cases, proving incontestably 
that an ox that has been once attacked is not the less susceptible 
to after impression ” 
The clinical professor at the Royal Veterinary School at Lyons, 
in the compte-rendu of that school in 1816, says that “ an animal 
cured of a contagious malady is liable to a relapse, and may con- 
tract the same disease a second time, if he is exposed to infection.” 
He adds, “ new experiments on the boasted power of inoculation 
have shewn that that operation does not preserve the animal from a 
second attack of the same disease.” 
M. Leroi, who observed the ravages of typhus in Italy in 1795, 
says that he witnessed a relapse in nine beasts, seven months after 
their apparent cure. “ In another instance,” adds this author, “ I 
saw five beasts labouring under typhus; they seemed to be cured, 
and they continued apparently well for about ten months, when, 
typhus again appearing in the country, these beasts were once more 
attacked. Three of them died ; the other two once more got well. 
Some of his colleagues, and particularly Professor Volpi, have 
assured me that they have witnessed similar relapses. Then, in 
the face of statements so contradictory, and made by persons de- 
serving of the fullest credit, we must hesitate ere we acknowledge 
the boasted power of typhus, either to transmit to the healthy 
animal a mild disease of this description, or a permanent security 
from future attack. We must await the result of farther experi- 
ments on this very important subject.” 
E. Some other Advantages of Inoculation. — Messrs. Girard and 
VOL. XII. 4 c 
