5 
v. into granulations or new Flesh. 
living body, they required being repeated upon the surfaces 
of sores, before their results could establish the opinion I had 
adopted. 
Before I attempted to trace the changes met with in pus 
upon the surface of a sore, my first object was to become 
m re accurately acquainted with the appearance of the surface 
immediately under the newly secreted pus. That this surface 
might be examined under the most favourable circum- 
stances for such observation, 1 selected an ulcer upon the 
leg to which no application was made but straps of adhesive 
plaster and these only changed once in the twenty-four hours; 
and that time was chosen for the examination, which was 
made by a double convex lens, magnifying about eight times. 
Previous to the adhesive straps being taken off, the leg was 
laid upon a low table, so as to be immediately under the eye, 
and in the position in which haemorrhage from the small 
vessels was least likely to take place, and obscure the surface 
of the sore. 
That the observations might be made with greater accu- 
racy, I requested Mr. John Griffith, one of the pupils of St. 
George’s Hospital, to look at the sores, as well as myself, 
upon every occasion on which they were examined, and no 
change is mentioned to have taken place that was not dis- 
tinctly seen by us both. A healthy sore thus examined had 
the following appearance ; the surface was uneven being 
made up of eminences and hollows. The eminences con- 
sisted of small clusters of tortuous blood vessels, the hollows 
were filled with pus. After 'remaining exposed from five to 
ten minutes, the following alterations were distinctly seen to 
take place : a very thin pellicle covered the whole surface ; 
