sis Mr. Brodie’s Observations and Experiments 
to have no effect in prolonging the heart's action. On dis~ 
section, the inner membrane of the stomach was found slightly 
inflamed. 
Experiment 4. Two drams of arsenic acid dissolved in six 
ounces of water were injected into the stomach of a dog, by 
means of a tube of elastic gum, passed down the oesophagus. 
In three minutes he vomited a small quantity of mucus, and this 
occurred again several times. The pulse became less frequent, 
and occasionally intermitted. At the end of thirty-fi ve minutes 
the hind legs were paralysed, and he lay in a half sensible 
state. At the end of forty-five minutes he was less sensible ; 
the pupils of the eyes were dilated ; the pulse had fallen from 
140 to 70 in a minute, and the intermissions were frequent. 
After this, he became quite insensible ; convulsions took 
place, and at the end of fifty minutes, from the beginning of 
the experiment, he died. On opening the thorax, imme- 
diately after death, tremulous contractions of the heart were 
observed ; but not sufficient to maintain the circulation. The 
stomach and intestines contained a large quantity of mucous 
fluid, and their internal membrane was highly inflamed. 
These experiments were repeated, and the results, in all 
essential circumstances, were the same*. The symptoms pro- 
duced were, 1 , paralysis of the hind legs, and afterwards of 
the other parts of the body ; convulsions ; dilatation of the 
pupils of the eyes ; insensibility ; all of which indicate distur- 
bance of the functions of the brain : 2, a feeble, slow, inter- 
mitting pulse, indicating disturbance of the functions of the- 
heart. Where the heart has continued to act after apparent 
death, I have never, in any one instance, been able to pro-? 
long its action by means of artificial respiration, 3, pain in* 
