-27- " 
SAYERS, R. P.., YAUT, W. P., THOMAS, B. G, H.-, and BERGER ? -L. B. (107) 
Physiological response attending exposure to vapors of methyl bro- 
mide, methyl chloride, ethyl bromide, and ethyl chloride. U. S. 
Pub. Health Serv. 3ul. 185: 1-56. 1929. 
The purpose was to determine the effects cf these vapors es- 
caping in refrigeration plants. Guinea pigs were used. Short 
exposure to high concentration of the vapors produced similar symp- 
toms, anesthetic in character, excitement, rapid loss of equilibrium, 
struggling and running motion of the legs, followed by rapid recov- 
ery of those animals which had not died in the chamber. With low 
concentration of vapor and long exposure, the symptoms were similar— 
weakness, rapid pulse; convulsive, rapid respiration, with rales; 
and in some cases a frothy, bloody exudate from the nostrils; fol- 
lowed usually by death in 1 to 4 days. Ethyl chloride was the 
least toxic and methyl bromide the most. Addition of chemical 
agents to these refrigerants to serve as a v.-arning of their escape 
is suggested. 
SCHROTER, G. (108) 
Methyl bromide. German Patent 330,642, Nov. 25, 1917. 
Methane or methane-containing gas mixtures are passed with 
bromine over catalysts, particularly iron, at temperatures above 
200° C. 
SCFAJLER. _ (109) 
Vergiftung durch Brommethyl? Deut. Vrtljrschr. f. Offentl, 
Gsndhtspflege. 31: 696-704. 1899. 
Three cases of poisoning by methyl bromide are reported, one 
of which was fatal. These men worked with apparatus in which 
methyl bromide was made from methyl sulfate and sodium bromide. 
Experiments on rabbits, guinea pigs, and mice are described. All 
the animals were killed by the concentrations of methyl bromide 
ranging from 1 to 8 percent by volume. Symptoms observed in the 
animals were somnolence, running of nose, slowness of pulse, and 
cyanosis. 
SCE7APTZ, F. (110) 
Brommethyl in der Schadlingsbckampfung. Arztl. Sachverstandigcnztg. 
42: 258-259. 1936. 
The insccticidal use end the toxicology of methyl bromide are 
briefly discussed. 
SHEPARD, H. H. , and BUZICKY, A. W. (Ill) 
Further studies of methyl bromide as an insect fumigant. Jour. 
Econ. Ent. 32: 354-859. 1939. 
Laboratory tests wore continued in 1938 (see Fisk and Shepard 
29) with common insects that occur in houses or infest storod pro- 
ducts. Their susceptibility to methyl bromide and its effective- 
ness in comparison with that of other fuiaigants are shorn in a 
table. With 5 hours' exposure at 25° C. the median lethal concen- 
trations cf methyl bromide, chloropicrin, ethylene oxido, carbon 
