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for multiple exposure 2.4 grams per day. The hazards of aerosol formula- 
tions of chlordane can only be surmised.—- Lehman ( 288 ) . 
On the West coast only one case of dermatitis among pest control 
operators using chlordane has "been reported and the patient in the patch 
test showed sensitivity to both petroleum solvents and undiluted chlordane. 
It is concluded that chlordane is probably no more hazardous than many 
other standard products used in the industry. — Jacobs ( 238 ) . 
The council on Foods and Nutrition of the American Medical Associa- 
tion (17) in a recent statement called attention to the danger to public 
health created by the wide use of synthetic insecticides and urged that 
controls be placed on the sale of products of unknown or incompletely 
known toxicity. The effects of inhalation and skin absorption of these 
synthetics must be determined as well as their chronic toxicity to man. 
Toxicological information on chlordane has been summarized as 
follows: Iio cal effects ; - Chlordane is moderately irritating to the 
skin. This property is lost on dilution, as in insecticide formulations, 
and the warning sign of danger is lost. The insecticide is absorbed 
through the skin, and it has been estimated that daily exposure to about 
2. k grams in solution may be dangerous to man. S ymptoms : - The early 
signs are those of irritability of the central nervous system. This 
leads eventually into convulsions, which are followed by a period of de- 
pression with or without a final convulsion seizure. Fatal dose ,: - From 
the acute standpoint chlordane appears to be only about one-half as 
poisonous as DDT, but the side effects are such that in the final analysis 
the toxicity is about 5 times that of DDT. Therefore, the fatal dose 
lies somewhere between 6 and 60 grams. Fatal period : - The onset of 
symptoms is within 45 minutes after ingestion. Deaths occur occasionally 
within 24 hours, are frequent between the 48th and 96th hour, and if sur- 
vival extends to the 6th day, recovery is the rule. Pathology ,: - Inani- 
tion is a predominant observation in chronic poisoning, indicating a con- 
siderable disturbance in normal physiology. Of the vital organs, the 
liver bears the brunt of the poisoning, and the usual degenerative changes 
produced by chlorinated hydrocarbons are a constant finding. Treatment : - 
The usual measures should be adopted for removing the poison from the 
stomach and intestinal tract. Any additional treatment must be sympto- 
matic as no specific antidotes are known.— Lehman ( 290 ) . 
A comparison of the acute oral doses shows that the compounds 
arrange themselves in the following order from the most toxic to the 
least toxic: tetraethyl pyrophosphate, parathion, hexaethyl tetraphos- 
phate, toxaphene, gamma isomer of benzene hexachloride, DDT, chlordane, 
TDE, methoxychlor . Chronic feeding data indicate that parathion is the 
most toxic, the sequence being parathion, beta isomer of benzene hexa- 
chloride, chlordane, DDT, gamma isomer of benzene hexachloride, alpha 
isomer of benzene hexachloride, toxaphene, TDE, delta isomer of benzene 
hexachloride, methoxychlor. — Lehman ( 289 ). 
Additional reports on the toxicology of chlordane have been pub- 
lished by Lehman ( 291-295 ). Chlordane presents the greatest all-around 
hazards of the commonly used chlorinated insecticides and therefore has 
