72 MR. T. WHARTON JONES ON THE BLOOD-CORPUSCLE CONSIDERED IN 
Frog (par. 27.). In this state they look as if they had burst, but such is not the case 
in general. 
59. By the addition of water, the collapsed granule-cells become distended and 
their appearance is thus distinctly brought out. Fig. 1 a. represents the human gra- 
nule-cell in its coarsely granular stage thus distended ; the contained granules, it 
will be observed, are minute, and on attentive observation they are seen to be in active 
molecular motion. Fig. 2 b. represents the finely granular stage of granule-cell of 
human blood, distended by water. 
60. The granule-cell of human blood is sometimes seen to present, though not very 
strikingly, a clear spot indicating, as I think, the place of the nucleus, similar to that 
above represented in the case of the granule-cell of the Skate. 
61. When distended by the action of ’water the human granule blood-cell is about 
T ^V oth of an inch in diameter. 
62. Fig. 3 a. represents the granule-cell, coarsely granular stage, and fig. 4 the 
granule-cell in its finely granular stage of the blood of the Horse. Figs. 5 a. and 6 
represent the coarsely and finely granular stages of the granule-cell of the blood of 
the Elephant. It will be observed that the diameter of these cells is somewhat greater 
than that of the granule-cell of human blood, but the principal difference is the size of 
the contained granules in the coarsely granular stage. Whilst in the granule-cell, 
coarsely granular stage, of the Horse the granules may be estimated in round 
numbers at about I - n n th of an inch in diameter, those in the same cell of the Ele- 
phant are about — 0 - 1 00( J -tli, and those in the human granule blood-cell about ^- t - 0 - th. 
63. If, after the granule blood-cell has been distended by the action of water, very 
dilute acetic acid be added, the contained granules are dissolved, and a cellseform 
nucleus brought into view. Fig. 1 b. represents a human granule-cell so acted on ; 
fig. 3 b. a granule blood-cell of the Horse similarly acted on ; and fig. 5 b. a granule 
blood-cell of the Elephant in the process of being acted on by acetic acid. This last 
drawing was made before the granules were all dissolved, but when the cellseform 
nucleus was already distinctly in view. In the case of the cells here represented, as 
indeed in the case of many others, I watched the progress of the action of the acetic 
acid on the granules and the coming into view of the cellseform nucleus. 
64. If, before the addition of the acid, the granule-cell has not been distended by 
the action of water, and if the acid has not been much diluted, instead of one cellse- 
form nucleus of the size represented, and which in the human granule-cell may be 
about 3 ~ (j 1 5 o th of an inch in diameter, but larger in the Elephant and smaller in the 
Horse, an appearance of several smaller ones variously aggregated may be brought 
out. This, however, in opposition to what is generally believed, and in opposition to 
what I myself once believed, I can affirm most positively is merely an appearance 
artificially produced by the corrugating action of the acid on the walls of the single 
cellseform nucleus, altogether in the manner above shown to be the case with the 
cellsefonn nucleus in the corresponding cells of the blood of the Frog. 
