-16- 
would keep their noses to the ground but did not grate. The animals 
eventually recovered, probably due to removal of the DDT dust from the 
vegetation by wind, the tramping of the animals, and a slight rain. A 
month later the test was repeated. The animals behaved in the same 
manner as with the first treatment but again all recovered. One of the 
ewes was taken to the University of Southern California where the feed- 
ing experiment was continued. Beginning July 10, a dosage of 2 grams 
of DDT daily was administered orally by capsule for 11 days. No symptoms 
were notioeable and the dose was inoreased to 4 grams per day and con- 
tinued for 40 days* On August 30 still no symptoms were noticeable and 
the dose was further increased to 8 grams daily for 14 days and thai 16 
grams daily; death ensued 17 days later. After the dosage was increased 
to 16 grams a day pronounced nervous symptoms in the form of tremors of 
the hind quarters and pawing with the forelegs were soon observable. 
These symptoms became more pronounced until the animal was unable to rise 
from the ground and stand on all four legs or manage itself. Upon au- 
topsy the kidneys and liver showed moderate degeneration.— Cox (121 ) • 
A 5-percent solution of DDT in olive oil was given by stomach tube 
to rabbits. Crystalline DDT was isolated from the urine and feces.— 
Stohlman (339 ) • 
The presence of TOT in rabbit urine could not be verified by X-ray 
diffraction analyses but the metabolite di(p-chlorophenyi) acetic acid 
was isolated.— White and Sweeney (372) . 
Organic chlorine can be demonstrated in the urine of rabbits, cats, 
and dogs receiving DDT long in advanoe of any recognizable symptoms of 
poisoning. Experiments on the circulatory and respiratory responses to 
some typical drugs and to nerve stimulation in advanced DDT poisoning 
in cats indicate little deviation from the normal except for a lowered 
irritability of the peripheral vagi. Studies on the aetion of a series 
of hypnotics and related compounds in acute DDT poisoning in rats indi- 
cate good antidotal effects from urethane and to a lesser degree from 
dilantin. — Smith and Stohlman (326 ) • 
The ethoxy analog of DDT appeared less toxic than DDT when fed to 
white rats.— Prill et al. (297 ) • 
DDT in a 1-percent solution in liquid paraffin or olive oil showed 
very little effeot against notoedric mange on rats. In a 2-percent so- 
lution, it led to the death of some of the experimental rats after the 
development of marked hyperesthesia and frequent clonic muscular spasms. 
— Taylor (343 ) • In a later report Taylor (344 ) stated: 
"One of the rats that had been dressed with 1 percent DDT in liquid 
paraffin developed symptoms of intoxioation within 24 hours and 
died. Two other rats were subsequently dressed with a 10-peroent 
