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Speolfications 
The U. S. War and Navy Departments (356 , 357 ) have issued joint 
Army-Navy specifications covering DDT, both technical and aerosol grades. 
PHARMACOLOGY 
DDT was administered "by mouth, subcutaneous injection, inhalation, 
and cutaneous application to mice, rats, guinea pigs, and rabbits. It 
was concluded that DDT insecticides should be considered as practically 
harmless to mammals, including man. — Domenjoz (135) • 
The use of an aerosol containing 1 to 5 percent of DDT, 10 percent 
of cyclohexanone,and 89 to 85 percent of Freon should offer no serious 
health hazards when used under conditions such as are required for its 
use as an insecticide* The use of DDT in concentrations up to 10 percent 
in inert powders for dusting clothes, as in the extermination of lice, 
appears to offer no serious hazards because of the relative insolubility 
of DDT and the large particle size of the dust* Therefore, it does not 
reach the alveolar spaces* A 1 peroent DDT-Deobase mixture was found to 
be nontoxic to rabbits exposed for 48 minutes daily over a period of 4 
weeks* Its use as a fly spray, which involves only temporary and com- 
paratively moderate exposure to much lower concentrations, should be safe* 
However, owing to the fat-solvent properties of most petroleum distillates, 
irritation of the skin may follow heavy exposure. — Neal ( 273 ) ♦ 
Two aerosol mixtures, containing 3 and 2*5 percent of DDT, were test- 
ed on guinea pigs, rats, mice, monkeys, and dogs. Monkeys exposed for 
45 minutes daily to a single, initial concentration of 33*3 mg. of DDT 
per liter for 22 weeks and longer showed neither definite nervous symptoms 
characteristic of DDT nor signs of an injurious effect on the liver. For 
entomological purposes the initial concentrator of DDT in air, when used 
as an aerosol, is about 100 to 200 mg. per 1,000 cubic feet, correspond- 
ing to about 0.004 to 0*007 mg. per liter. In the inhalation experiments 
reported above, the initial concentration ranged from 19 to 33 mg. per 
liter, or 3,000 to 4,500 times the desired entomological concentration* 
It is evident, therefore, that the desired entomological concentration 
offers no health hazard. The contamination of the skin from such residues 
as are produced by -the desired lnsecticidal concentration of DDT in air 
is so little that it will not injure humans. However, careless handling 
of DDT residues, as in the filling of the aerosol bombs, may result in 
such severe contamination of the skin, especially with repeated exposure, 
that toxic effeots might occur in humans*— Neal et al. (272 ) * 
Aerosol No. 305, containing 2 percent of pyrethrum extract (20 per- 
cent pyrethrins), 3 percent of DDT (aerosol grade), 12 peroent of APS-202 
and 83 percent of Freon-12, was tested on mice, rats, and dogs* The 
