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Berneles, Bemberen, and Maldonedo (7) in 1932 reported on the 
therapeutic uses of cube in Peru. The first case of me.nge treated was one 
of generalized scebiosis, with en edema more or less diffuse, dyspneal, end 
olioiretic. Rubbings vere given with a rotenone solution ("Sernol") es the 
only treatment, changing the underclothes of the patient as frequently as 
is customary in these cases. The sick person stated that from the first 
day of treatment the itching had diminished and by the third day the edema 
began to decrease and the diuresis to increase. By the sixth day there were 
no traces of dropsical phenomena and the skin affection had disappeared. In 
view of this result, the remedy was used on 20 more patients, including each 
sex and various ages and conditions, and it invariably effected a cure after 
4 or 5 daily rubbings. In a case in which mange vras complicated with skin 
lice the curative success in the two diseases was shown. "Piojol" (a pro- 
prietary rotenone preparation) not only kills the body louse ( Pedi cuius 
humanus corpois Beg.) with certainty, but also destroys the eggs, or nits. 
Hanson (72) in 1932 reported that a mixture of 1 part of fresh, finely 
ground derris root and 2 -certs of flour, tac, or some other carrier, applied 
as a dust, is a cood remedy for the control of the usual species of flea 
found on foxes. In discussing this paper C. W. Bower stated that good results 
asainst ear mites in foxes and cats had been obtained by scabbing the ears 
and bathing the head. and. neck in an 8- to 10-percent active solution of derris 
root. Generally one application was sufficient. Dr. Hanson replied: 
As regards derris root for ear mites, Br. w . L. Chandler, of 
Michigan State Collere, apparently was the first to introduce this 
drug as a remedy for ear mites. He proposed its use in a soap 
solution. This, like the aqueous solution,- fails, however, to 
possess ability to cut and dissolve eerwax, an ability which is a 
desirable, if not essential," property of an ear-manrie remedy in 
order that it prove effective and practicable. 
. Gotze (67) in 1933 compared derris suspension with oil of birch and 
another proprietary "Oil aa" for control of "Grabmilbenreu.de" [sarcbptic 
mangefj on 1-1/ 2- year- old bulls. This derris was applied as for warble 
fly larvae, end produced excellent results, with no disturbance to the 
health of the animals; whereas the oils, while giving equal control, produced 
reddening and swelling of the skin, as ^ell as other general disturbances. 
The derris can be applied without sheering the enimels. 
Spoon ( 139 ) in 1933 concluded thet rotenone cen be of service in horti- 
culture for the control of spider mites on various plants. 
The Wageningen Plentenziektenkundige Dienst ( 154 ) in 1933 reported the 
results of tests on spider mites in the Netherlands. The derris powder used 
in the experiments contained 2 percent of rotenone, end was added to 50 parts 
of 1-percent soap solution (l part rotenone to 2,500 perts of water). Pure 
rotenone was dissolved in 25 parts of acetone, and the acetone solution was 
added to 200 parts of water (l part of rotenone to 5,000 parts of water). 
