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extracted substances from derris root, with the exception of rotenone, and 
used at the rate of 20 cc. end 60 cc. per liter of soap solution, proved to 
he very successful in curing mange of cattle caused by this mite. 
Scheiner ( 133 ) in 1934 found that Derrisol (3 percent rotenone) made by 
Bengen & Co., Hannover, Germany, was more effective than Fanderran (5 percent 
rotenone) made by E. Merck, Darmstadt, Germany, used in water solutions in 
simple rashes to control chor'ioptic mange of cattle caused by this mite. Two 
washes were sufficient for 100-percent control of chorionic mange, if used 
in sufficiently strong solution (un to 10 percent in water) . 
D emodex folliculorum bovis ' Stiles 
The United States Department of Agriculture, Bureau of Animal Industry 
( 148 ) , in 1940 reported tests to control demodectic mange. External appli- 
cations used on cattle infected with demodectic mange, in the form of dips 
or sprays, included arsenical dip, fused-bentonite-sulfur dip, and a saturated 
solution of borax. ^he treatments as applied failed to prevent the develop- 
ment of, or to eradicate, demodectic mange caused by this mite. The same 
statement applies to rotenone in oil and acetone, and to proprietary prepa- 
rations that had been rejjorted to control the disease, when these materials 
were applied direct to the lesions. 
Demodex can i s Leydig, the dog follicle mite 
Crane (46) in 1933 reported on tests with rotenone against follicular 
mange, caused by D. folliculorum canis , on dogs at the Small Animal Clinic 
of the New York State Veterinary College at Cornell University. In 11 of the 
13 cases in which it was used, an unusually rapid recovery followed the 
application of rotenone. The remaining two cases recovered in the time usuall; 
necessary for the standard remedies. These cases included several that had 
not responded to the citrine-ointment dressing, which is the standard treat- 
ment in the Small Animal Clinic. Rotenone has the additional advantages of 
being entirely nontoxic and is not greasy or dirty to ap-^ly. 
Eastman (56) in 1935 and Morris ( 109 ) in 1936 reported control of 
follicular mange on dogs by the use of a special oil solution containing 
rotenone. 1 he preparation, called Solution 34 AR 348, is manufactured by 
Merck and Company, Rahway, N. J. It is thoroughly applied by hand, either 
into and around the infested areas or over the entire body. Thorough and 
almost rough message appears to hasten improvement. The preparation should 
not be permitted to reach the conjunctival membrane or the cornea. Eighty-six 
cases in 12 States were treated by 24 veterinarians- "ho reported 84 cases as , 
complete recoveries. 
The United States Department of Agriculture, Food and D r ug Administration 
( 151 ) , in 1936 reported that during 1935 many preparations containing derris 
extracts and rotenone appeared on the market labeled as a specific treatment 
for demodectic mange of dogs and other animals. Preliminary tests of sr 2 
preparations have not confirmed the claims made for their efficacy. 
