ANIMALS SUSCEPTIBLE TO EUPATORIUM POISONING. 
The author.-* experiments were with cattle and sheep. Definite 
feeding experiments made by others have proved the toxicity of 
Eupatorium for horses, and extracts from the plant have poisoned 
cats, dogs, and guinea pigs. So far as reported experimentation goes, 
it appears that no animals are immune to the toxic principle of the 
plant. In regard to man the definite evidence is hardly conclusive, 
in spite of a number of instances in which the plant or an extract is 
said to have been poisonous. Some of these cases are clearly apocry- 
phal. But, on the whole, there seems to be little doubt that human 
beings may be poisoned by the plant. 
TOXICITY OF THE PLANT. 
There is very little difference between the toxic and lethal doses, 
as determined by experiment. This does not mean that no poisoned 
animals recover, but does show the serious character of cases of 
poisoning. Generally speaking, the fatal dose for sheep is about G 
per cent of the animal's weight, and for cattle about 10 per cent. 
Sheep, consequently, are somewhat more susceptible than cattle. 
Although there is some evidence that the toxic dose is smaller 
when the material is given in a short time, this difference is com- 
paratively slight. It appears from the experimental cases that the 
elimination of the toxic substance takes place very slowly, so that 
there is a distinct cumulative effect. This was evident both in the 
cattle and in the sheep. 
The plant is poisonous when dried, but it does not have as much 
effect as when in a fresh state, so that while Eupatorium in hay 
may be poisonous it is not so dangerous as the. fresh plant. 
So far as experimental work has gone, it seems quite clear that 
the flesh of poisoned animals is not harmful to other animals that 
may eat it. 
Poisoning by Eupatorium is produced by a poisonous principle in 
the plant, and not by disease germs carried by the plant to the 
animals. 
RELATIONSHIP BETWEEN EUPATORIUM POISONING AND MILK 
SICKNESS. 
There is no question but that Eupatorium urticce folium is- poisonous 
and produces a line of symptoms closely resembling those said to be 
typical of milk sickness in cattle and other animals. Most cases 
of the so-called milk sickness in cattle occur in localities where this 
plant grows. Field eases seen by the authors have the same symp- 
toms as those which have been observed in experimental animals. 
and have been diagnosed as intoxication by Eupatorium urtlccpjoVum . 
There seems little doubt that manv if not most cases of milk sick- 
