446 
BUIylvETiN OF THE BUREAU OF FISHERIES. 
In considering the prevalence of goiter in the villages of Gilgit the villages are dealt with in order, 
from that highest on the water supply to that lowest (see sketch of water supply). The figures are given 
in the following table: 
Village. 
Popula- 
tion. 
Houses. 
Infected houses. 
Persons 
infected 
in 
infected 
houses. 
Total 
popula- 
tion 
goitrous. 
Number. 
Number. 
Number. 
Per cent. 
Per cent. 
Per cent. 
I. Basin 
93 
IS 
9 
60. 0 
21. 2 
II. 8 
2. Umpharis 
38s 
66 
42 
63. 6 
28.3 
20. 0 
3. Damyal 
181 
30 
20 
66.6 
30-3 
18.8 
4. Majunpharri 
718 
108 
68 
63. 2 
24. 2 
20. 0 
5.6. kyk 
229 
33 
23 
71 - 5 
30- 0 
26. 9 
7. Sonyar 
4 S 8 
63 
52 
82. 5 
30. 0 
24 - 5 
8. Kashrote 
128 
24 
21 
87. 0 
36.0 
45-6 
It is quite clear that McCarrison has observed conditions which are remarkably 
comparable to the conditions found in the Craig Brook hatchery where we originally 
found the increase of the disease from above downward in the ponds, with absence of 
the disease in the two uppermost ponds fed with individual spring water supply 
(fig. 78, p. 429) ; also to the conditions which we have described at Cold Spring Harbor. 
The age incidence of visible manifestations of this disease including both red floors 
and tumors affords material for a comparison of the incidence of the disease as we have 
observed it in fish and that of goiter in the inhabitants of the villages of Chitral and 
Gilgit Valleys, as recorded by McCarrison, as well as that of goiter in school children 
as given by Schittenhelm and Weichardt. McCarrison examined 646 inhabitants of 
the villages of Chitral, of which 277 were children under 15, and 369 adults. At 5 
years of age male children showed 40 per cent, female 22 per cent. The incidence of 
the disease rises rapidly to 15 years where the males showed 74 per cent, females 59^ 
per cent. From this age it rapidly fell in both cases so that at 25 years of age males 
showed 40 per cent, females 24 per cent. From 25 years on, the incidence in females 
again rose, until the age of 45 when 62 per cent were affected, the males having steadily 
fallen to 23 per cent at the same age period. In Gilgit the total population examined 
was 1,533, of which 705 were children under 15 years and 828 adults. The incidence 
for males and females varies slightly. At 5 years of age 2 per cent of the males and 
at 15 years of age 16 per cent of the n^ales and 20 per cent of the females were affected. 
In this locality the incidence steadily rose to 40 years of age when 45 per cent of the 
males and 36 per cent of the females were affected. McCarrison states that in Chitral 
23 per cent of children under i year of age who are still being suckled suffer from this 
disease in the village of Awi, and in another village, Miragram, the percentage figure 
w'as even higher than this, reaching 61.5 per cent. The mothers had in all cases been 
the subject of the disease and frequently the fathers also. What proportion of these 
cases were congenital and what acquired he was unable to determine. 
Schittenhelm and Weichardt state that in a typical goitrous community in Bavaria 
the incidence of goiter as expressed by demonstrable enlargement of the thyroid is, 
from 2 to 6 years of age, 42 per cent; 6 to 9, 72.4 per cent; 9 to 13, 89.6 per cent; and 
