26 
The mouse which had received the thyroid recovered from a dose 
of acetonitrile about six times as large as that fatal to the controls. 
Less than 5 mgms. of thyroid had led to the physiological neutrali- 
zation of about 51.8 mgms. of acetonitrile. 
Series V. 
A. HOG THYROID; 0.33 PER CENT IODINE. 
Date. 
Weight 
of mouse. 
Remarks. 
1907. 
Januarv 9 
19.73 j 
Feeding of cakes, each containing 0.0001 gm. thyroid, begun. 
14 
19.50 
17 
18.82 
19 ; 
18.80 
Acetonitrile, 18.8 mgms., i. e., 1 mgm. per gm. mouse. Survived. 
January 9 
13.83 
Thyroid as above. 
14 
15. 45 
17 
14.47 
19 i 
13.65 , 
20 1 
13-65 
Acetonitrile, 17.75 mgms., L e., 1.3 mgms. per gm. mouse. Died 2 \ hours. 
B. CONTROLS. 
1907. 
January 9 ‘ 16. 45 Feeding of cakes without thyroid begun. 
14 15.52 
17 ! 15.16 
19 15. 07 Acetonitrile, 5.73 mgms., i. e., 0.38 mgm. per gm. mouse. Survived. 
Januarv 9 15.25 Cakes as above. 
14 15.90 
17 14.70 
19 13.82 
20 1.3-43 Acetonitrile, 5.51 mgms., i. e., 0.41 mgm. per gm. mouse. Died 5 hours. 
Summary . — The results of these experiments may be summarized 
as follows: 
Gm. 
thyroid fed 
daily. 
Mgm. I in 
thyroid. 
Weight of 
mouse in 
gms. 
Amount of acetonitrile 
in mgms. 
Result. 
Per mouse. 
Per gm. 
mouse. 
A 
0.0001 
0.00033 
18.80 
18.8 
1.0 
Survived. 
.0001 
.00033 
13.65 
17. 75 
1.3 
Died. 
B 
0 
0 
15. 07 
a 73 
.38 
Survived. 
0 
0 
13.43 
5. 51 
.41 
Died. 
The mouse which had received thyroid recovered from approxi- 
mately two and one-half times the dose of acetonitrile fatal to the 
controls. A total of about 1 mgm. thyroid had enabled the mouse 
to resist 11.5 mgms. acetonitrile. 
We have performed no experiments for the special purpose of 
determining either the maximum amoimt of nitrile which may be 
neutralized under the influence of thyroid or the minimum amount 
