40 
D. CONTROLS. 
Date. 
Weight of 
mouse. 
Remarks. 
1907. 
April 27 
13.63 
Cakes without thyroid. 
May 3 
13.95 
4 
13.52 
Acetonitrile, 3.38 mgms., i. e‘., 0.25 mgm. per gm. mouse. Survived. 
April 27 
15.62 
Cakes as above. 
30 
16.65 
May 3 
15.43 
7 
14.91 
10 
14.35 
14 
14.02 
Acetonitrile, 3.93 mgms., i. e., 0.28 mgm. per gm. mouse. Died 2£ hours. 
April 27 
13. 12 
Cakes as above. 
30 
13.07 
May 3 
12.33 
4 
12.02 
7 
11.45 
10 
11.55 
13 
11.25 
Acetonitrile, 3.94 mgms., i. e., 0.35 mgm. per gm. mouse. Died 7 hours. 
April 27 
20.57 
Cakes as above. 
30 
21.40 
May 3 
20.00 
4 
20.32 
Acetonitrile, 10.16 mgms., i. e., 0.5 mgm. per gm. mouse. Died 10 hours. 
Summary . — These results may be tabulated as follows: 
Thyroid. 
Gm. thy- 
roid fed 
daily. 
Percentage 
of iodine 
in thyroid. 
Mg. I in 
thyroid fed. 
Fatal dose of aceto- 
nitrile in mgms. 
per gm. mouse. 
Recovered. 
Died. 
A. Maltese kid 
0.05 
0 
0 
0.7 
0.9 
B. Children 
.05 
0 
0 
1.2 
C. Guinea pig . 
.007 
.05 
.0035 
2.0 
D. Controls 
.25 
.28 
Unfortunately the experiments were not sufficiently numerous to 
permit of a determination of the fatal dose in all cases. The guinea 
pig thyroid (C) protected against more than twice as much aceto- 
nitrile as did the thyroid of the Maltese kid (A) ; since seven times as 
much of the latter as of the former was given, we may consider that 
the guinea pig thyroid is more than fourteen times as active as that of 
the Maltese kid. Another point of interest in this series is that the 
children’s thyroid (B) was more active than the Maltese kid thyroid; 
this shows that there are differences in activity of different u iodine 
free” thyroids. 
Owing to lack of material but few experiments were made with 
smaller amounts of children’s thyroid and the results were not 
altogether satisfactory; 1 mgm. fed daily for ten days had slight, if 
any, effect. 
