D. THYRADEX: a 0.085 PER CEXT IODINE. 
Bate. 
Weight of 
mouse. 
Remarks. 
1908. 
Mav 19 
15.50 
Feeding of cakes each containing 0.00125 gm. thyraden begun. 
23 
14.81 
<77 
13.12 
Acetonitrile, 9.18 mgms., i. e.. 0.7 mgm. per gm. mouse. Survived. 
Mav 19 
18.46 
Thyroid as above. 
23 
17.30 
28. 
16.23 
Acetonitrile, 12 98 mgms., i. e., 0.8 mgm. per gm. mouse. Survived. 
Mav 19 
15. 19 
Thyroid as above. 
23 
15.03 
97 
14.65 
Acetonitrile, 13.19 mgms. , i. e.. 0.9 mgm. per gm. mouse. Died 1 hour. 
Mav 19 
16.69 
Thvroid as above. 
23 
14.53 
97 
14.02 
Acetonitrile, 14.02 mgms.. i. e., 1 mgm. per gm. mouse. Died 1 \ hours. 
a This is a commercial lactose trituration of dried thyroid claimed to be standardized to contain 0.07 per 
cent iodine. Two specimens examined by us were found to contain slightly more iodine than this, viz, 
0.0S5 per cent. 
E. CONTROLS. 
1908. 
Mav 19 
15.79 
Feeding of cakes without thyroid begun. 
' 23 
15.65 
97 
15.87 
Acetonitrile, 3.97 mgms., i. e., 0.25 mgm. per gm. mouse. Survived. 
May 19 
15.66 
Cakes as above. 
23 
15.24 
97 
16.02 
28. 
Acetonitrile, 4.17 mgms., i. e., 0.26 mgm. per gm. mouse. Died 4| hours. 
Mav 19 
17.55 ; 
! Cakes as above. 
’ 23 
18.15 | 
26 
18.10 
1 Acetonitrile, 5.43 mgms., i. e., 0.30 mgm. per gm. mouse. Died 2 hours. 
Mav 19 
11.80 
' Cakes as above. 
23 
11.70 
97 
10.34 
Acetonitrile, 3.31 mgms., i. e., 0.32 mgm. per gm. mouse. Died 3 hours. 
Summary . — The results of the above experiments may be sum- 
marized as follows: 
Thyroid. 
Gm. thy- 
roid fed 
daily. 
Percentage 
of iodine 1 
in thy- 
roid. 
Mgm. I in 
thyroid 
fed. 
i Fatal dose of aceto- 
nitrile in mgm. 
per gm. mouse. 
Recovered. 
Died. 
A. Alaskan bear 
0.005 
0 
0 
0.48 
0.52 
B . \oudad 
.005 
0 
0 
. 40 
C Black leopard 
.005 
.01 
.0001 
.50 
D. Thvraden 
.00125 
.085 
.0011 
.80 
.90 
E. Controls 
.25 
.26 
