53 
Great care is also required in making the cakes. In some of our 
experiments we have worked with 1 part of thyroid mixed with 
40,000 parts of cracker dust. It is obvious that a uniform distribu- 
tion of such a small amount of thyroid in such a large amount of 
cracker dust by ordinary laboratory methods requires considerable 
care. That, however, remarkably concordant results may be 
obtained by this method is sufficiently demonstrated by the experi- 
ments which follow. 
Series I. 
A. SHEEP THYROID; 0.087 PER CENT IODINE. 
Date. 
Weight 
of mouse. 
Remarks. 
1907. 
November 22... 
22. 63 
Feeding of cakes each containing 0.005 gm. thyroid commenced. 
26... 
22.45 
29... 
21.62 
December 2... 
21.52 
Acetonitrile, 38.74 mgms., i. e., 1.8 mgms. per gm. mouse. Survived. 
November 22... 
16.32 
Thyroid as above. 
26... 
16.42 
29... 
16.59 
December 2... 
16.07 
3... 
16.32 
Acetonitrile, 32.64 mgms., i. e., 2 mgms. per gm. mouse. Died 1§ hours. 
November 22. . . 
20.39 
4 » 
Thyroid as above. 
26... 
19.44 
29... 
19.10 
December 2... 
18.59 
3... 
18.87 
Acetonitrile, 41.5 mgms., i. e., 2.2 mgms. per gm. mouse. Died 2 hours. 
November 22... 
21.79 
Thyroid as above. 
26... 
21.57 
29... 
20. 70 
December 2... 
19. 63 
3... 
18. 26 
Acetonitrile, 45.65 mgms., i. e., 2.5 mgms. per gm. mouse. Died 1 hour. 
B. SHEEP THYROID; 0.17 PER CENT IODINE. 
1907. 
November 22... 
18.52 
Feeding of cakes each containing 0.005 gm. thyroid begun. 
26... 
18. 35 
29... 
18. 33 
December 2... 
17.04 
Acetonitrile, 34.1 mgms., i. e., 2 mgms. per gm. mouse. Survived. 
November 22. . . 
22.92 
Thyroid as above. 
26... 
21. 00 
29... 
21.65 
December 2 ... 
20. 64 
Acetonitrile, 57.79 mgms., i. e., 2.8 mgms. per gm. mouse. Survived. 
November 22... 
16.00 
Thyroid as above. 
26... 
16.39 
29... 
16.56 
December 2 ... 
16. 70 
3... 
15.74 
Acetonitrile, 55.09 mgms., i. e., 3.5 mgms. per gm. mouse. Survived. 
November 22... 
20. 28 
Thyroid as above. 
26... 
18. 41 
29... 
18.35 
December 2 ... 
17.48 
3... 
17.08 
Acetonitrile, 78.3 mgms., i. e., 4 mgms. per gm. mouse. Died f hour. 
