Series II. 
A. DOG THYROID; 0.111 PER CENT IODINE 
Date. 
Weight 
of mouse. 
Remarks. 
1908. 
May 9 
16 
18 
15.83 
14.05 
13. 94 
Feeding of cakes each containing 0. 0015 gm. thyroid begun. 
Acetonitrile, 64.14 mgms., i. e., 4.6 mgms. per gm. mouse. Survived. 
B. CONTROLS. 
1908. 
Mav 9 
19.00 
Feeding of cakes without thyroid begun. 
* 16 
19.86 
18 
19.52 
Acetonitrile, 5.47 mgms., i. e., 0.28 mgm. per gm. mouse. Died 6 hours. 
Summary . — The results of these experiments may be summarized 
as follows : 
Gm. thy- 
roid fed 
daily. 
Mgm. I in 
Weight of 
mouse in 
gms. 
Amount of acetonitrile 
in mgms. 
Result. 
thyroid. 
Per mouse. 
Per gm. 
mouse. 
0. 0015 
0 
0. 0017 
0 
13. 94 
19.52 
64.14 
5.47 
4.6 
.28 
Survived. 
Died. 
The mouse which had received the thyroid recovered from more 
than sixteen times the relative dose fatal to the controls. A total of 
less than 15 mgms. of thyroid had led to the physiological neutraliza- 
tion of at least 60.24 mgms. acetonitrile. 
Series III. 
A. SHEEP THYROID; 0.19 PER CENT IODINE. 
Date. 
Weight 
of mouse. 
Remarks. 
1908. 
March 28 
15.93 
Feeding of cakes each containing 0.001 gm. thyroid begun. 
31 
14. 88 
April 3 
15. 20 
7 
14.33 
8 
14. 74 
Acetonitrile, 67.80 mgms. , i. e., 4.6 mgms. per gm. mouse. Survived. 
March 28 
16. 85 
Thyroid as above. 
31 
14. 24 
April 3 
14.90 
7 
14.40 
Acetonitrile, 71.12 mgms., i. e., 4.8 mgms. per gm. mouse. Died 1| hours. 
B. CONTROLS. 
1908. 
March 28 
14. 30 
Feeding of cakes without thyroid begun. 
31 
12. 88 
April 3 
13. 15 
Acetonitrile, 5.06 mgms., i. e., 0.4 mgm. per gm. mouse. Survived. 
7 
12. 64 
March 28 
15. 35 
Cakes as above. 
31 
15. 06 
April 3 
13. 17 
7 
12.60 
> 
8 
12. 04 
Acetonitrile, 5.06 mgms., i. e., 0.42 mgm. per gm. mouse. Died If hours. 
