58 
C. SHEEP THYROID: 0.192 PER CENT IODINE. 
Date. 
Weight 
of mouse. 
Remarks. 
1907. 
November 28. . . 
18.07 
Feeding of c-akes. each containing 0.002 gm. thyroid, commenced. 
30. . . 
17.85 
December 3... 
17.50 
6-.-I 
16.77 
7... 
17.24 
Acetonitrile. 37.93 mgms., i. e., 2.2 mgms. per gm. mouse. Survived. 
November 28... 
16.00 i 
Thyroid as above. 
30... 
16.85 
December 3. . . 
16.07 
6— 
15.47 ! 
14.92 
Acetonitrile. 41.78 mgms... i. e., 2.8 mgms. per gm. mouse. Survived. 
November28... 
21.85 1 
Thyroid as above. 
30.. J 
20.05 | 
December 3... 
22.40 i 
6— 
20.92 | 
8... 
21.16 ! 
Acetonitrile, 69.83 mgms., i. e., 3.3 mgms. per gm. mouse. Survived. 
November 28. . . 
17.67 
Thyroid as above. 
30... 
15.59 
December 3... 
16.07 
6— 
16.17 
8..J 
15.71 
Acetonitrile, 58.13 mgms., i. e. , 3.7 mgms. per gm. mouse. Died, one-half hour. 
D. CONTROLS. 
1907. 
November 28. . . | 
21.77 
Feeding of cakes without thyroid begun. 
30— 
21.92 
December 3... 
21.09 
6... 
20.78 
8— 
20.57 | 
Acetonitrile, 5.14 mgms., i. e., 0.25 mgm. per gm. mouse. Died, about 2 hours. 
November 28... 1 
24.50 
Cakes as above. 
30. ..! 
23.96 
December 3... 
24.51 
6— 
24.32 
8... 
24.51 
Acetonitrile, 7.35 mgms.. i. e., 0.3 mgm. per gm. mouse. Died li hours. 
November 28... 
21.86 1 
Cakes as above. 
30... 
21.50 ! 
December 3... 
21.52 | 
6— 
20.74 
8... 
21.50 
Acetonitrile, 7.53 mgms., i. e., 0.35 mgm. per gm. mouse. Died 3 hours. 
Summary . — The results of the above experiments may be summa- 
rized as follows: 
A 
B 
c 
D. Controls 
Gm. thy- 
roid fed 
daily. 
Percentage 
of iodine i 
in thyroid. | 
Mgm. I in 
thyroid 
fed daily. 
Fatal dose of aceto- 
nitrile in mgms. 
per gm. 
Recovered. 
Died. 
0.002 
.006 
.002 
0.061 
.061 
.192 
0.00122 
.00366 
.00384 
1.1 
3.1 
3.3 
1.2 
3.6 
3.7 
.25 
Two thousandths of a gram of thyroid containing 0.192 per cent 
iodine protected mice against as much acetonitrile as did 0.006 gm. 
thyroid containing but 0.061 per cent iodine. 
