60 
C. SHEEP THYROID; 0.1 PER CENT IODINE. 
Date. 
Weight 
of mouse. 
Remarks. 
1908. 
January 15 
20.00 
Feeding of cakes each containing 0.005 gm. thyroid commenced. 
18 
20.30 
21 
20.27 
24 
19. 70 
Acetonitrile, 68.95 mgms., i. e., 3.5 mgms. per gm. mouse. Survived. 
January 15 
22.52 
Thyroid as above. 
18 
21.51 
21 
21.36 
24 
20.72 
25 
21.21 
Acetonitrile, 95.45 mgms., i. e., 4.5 mgms. per gm. mouse. Survived. 
January 15 
22.72 
! Thyroid as above. 
18 
22.98 
21 
22.50 
24 
22.22 
26 
21.75 
Acetonitrile, 108.75 mgms* i. e., 5 mgms. per gm. mouse. Died 1J hours. 
| 
January 15 
21. 55 
Thyroid as above 
18 
22.58 
21 
22.68 
24 
22. 70 
26 
22.50 
Acetonitrile, 123.75 mgms., i. e., 5.5 mgms. per gm. mouse. Died 2k hours. 
D 
. SHEEP THYROID; 0.19 PER CENT IODINE. 
1908. 
January 15 
23.13 
Feeding of cakes each containing 0.005 gm. thyroid commenced. 
18 
21.30 
21 
22.12 
24 
21.06 1 
Acetonitrile, 84.24 mgms., i. e., 4 mgms. per gm. mouse. Survived. 
January 15 
24.17 
Thyroid as above. 
18 
25.28 
21 
24 44 
24 
23.40 
26 
24 25 
Acetonitrile, 133.38 mgms., i. e., 5.5 mgms. per gm. mouse. Died 2 hours. 
January 15 
21.67 
Thyroid as above. 
18 
21.80 
21 
20.90 
24 
19.62 
26 
19.38 
Acetonitrile, 116.3 mgms., i. e., 6 mgms. per gm. mouse. Died 5 hours. 
The experiments on the controls for this series were somewhat 
irregular, but the fatal dose was apparently between 0.4 and 0.5 mg. 
acetonitrile per gram mouse. 
SUMMARY. 
A 
B 
C 
D 
Controls 
Gm. thy- 
roid fed 
daily. 
Percentage 
of iodine 
in thyroid. 
Mgm. I in 
thyroid fed 
daily. 
Fatal dose of ace- 
tonitrile in mgms. 
per gm. 
Recovered. 
Died. 
0.001 
0.1 
0.001 
L 4 
L 7 
.001 
.19 
.0019 
2 7 
3.0 
.005 
. 1 
.005 
4 5 
5.0 
.005 
. 19 
.0095 
40 
-4(?) 
5. 5 
• 5(?) 
